Dr Jason Berwick
PhD, Bsc(Hons)
Department of Psychology
Reader in Neurophysiology
Assistant Faculty Director of Research and Innovation
j.berwick@sheffield.ac.uk
+44 114 222 6574
+44 114 222 6574
+44 114 222 6597
(fax)
Alfred Denny Building
Full contact details
Dr Jason Berwick
Department of Psychology
Alfred Denny Building
Western Bank
Sheffield
S10 2TN
Department of Psychology
Alfred Denny Building
Western Bank
Sheffield
S10 2TN
- Profile
-
I joined the Department of Psychology in 1996 as a PhD student in the laboratory of Professor John Mayhew. Our research uses multimodal imaging and electrophysiological techniques to measure a mechanism in the brain called Neurovascular coupling (NVC). This mechanism provides the image contrast for modern neuroimaging technologies such as functional magnetic resonance imaging (fMRI) and the early focus of the research was to understand NVC in order to provide a better understanding and interpretation of fMRI signals.
My position was made permanent in 2007 and our research has now expanded to investigate in neurodegenerations with a particular focus on Alzheimer’s disease and focal cortical epilepsy. Our laboratory is focussed on not only understanding NVC decline in disease but also in the development of novel therapies that target the cerebrovascular system to slow down or halt disease progression.
I am in the privileged position in that my job is also my hobby and I am passionate about encouraging students to experience research and to help develop the next generation of scientists.
- Qualifications
-
- Bsc (Hons) Anatomy and Cell Biology, University of Sheffield.
- PhD Neuroscience, University of Sheffield
- Research interests
-
Neurovascular coupling is a mechanism that ensures active regions of the brain are supplied with enough oxygen and glucose to function properly. Although first discovered over 130 years ago, to this day we still do not have a complete understanding about how neurovascular coupling works. Our laboratory uses multimodal neuroimaging and electrophysiological techniques to measure and understand neurovascular coupling in normal function, how it goes wrong in disease and importantly to develop new therapies based on enhancing/restoring cerebrovascular function.
Current projects include:
- Neurovascular coupling and breakdown in Alzheimer’s Disease
- Neurovascular coupling in Focal Cortical Epilepsy
- Interpretation of the negative BOLD fMRI signal
- The role of temperature in Neurovascular coupling.
- The interaction between Atherosclerosis and Alzheimer’s Disease
- Publications
-
Show: Featured publications All publications
Featured publications
Journal articles
- Bidirectional alterations in brain temperature profoundly modulate spatiotemporal neurovascular responses in-vivo. Communications Biology, 6.
- Enhanced cerebral blood volume under normobaric hyperoxia in the J20-hAPP mouse model of Alzheimer’s disease. Scientific Reports, 10(1). View this article in WRRO
- Key Aspects of Neurovascular Control Mediated by Specific Populations of Inhibitory Cortical Interneurons. Cerebral Cortex, 30(4), 2452-2464. View this article in WRRO
- Neurovascular coupling preserved in a chronic mouse model of Alzheimer’s disease: Methodology is critical.. Journal of Cerebral Blood Flow and Metabolism. View this article in WRRO
- The time course of recognition memory impairment and glial pathology in the hAPP-J20 mouse model of Alzheimer’s disease. Journal of Alzheimer's disease : JAD. View this article in WRRO
- Neurovascular Dysfunction in Vascular Dementia, Alzheimer’s and Atherosclerosis. BMC Neuroscience, 19. View this article in WRRO
- Physiological and pathological brain activation in the anesthetized rat produces hemodynamic-dependent cortical temperature increases that can confound the BOLD fMRI signal.. Frontiers in Neuroscience, 12. View this article in WRRO
- Seizure epicenter depth and translaminar field potential synchrony underlie complex variations in tissue oxygenation during ictal initiation. NeuroImage, 171, 165-175. View this article in WRRO
- Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology. Clinical Science, 132(8), 851-868. View this article in WRRO
- Review: Neuropathology and behavioural features of transgenic murine models of Alzheimer's disease. Neuropathology and Applied Neurobiology, 43(7), 553-570. View this article in WRRO
- Decreased haemodynamic response and decoupling of cortical gamma-band activity and tissue oxygen perfusion after striatal interleukin-1 injection. Journal of Neuroinflammation, 13(1), 195-195. View this article in WRRO
- Comparison of stimulus-evoked cerebral hemodynamics in the awake mouse and under a novel anesthetic regime. Scientific Reports, 5. View this article in WRRO
- LRP-1-mediated intracellular antibody delivery to the Central Nervous System. Scientific Reports, 5, 11990-11990. View this article in WRRO
- Long-Latency Reductions in Gamma Power Predict Hemodynamic Changes That Underlie the Negative BOLD Signal. Journal of Neuroscience, 35(11), 4641-4656. View this article in WRRO
- Contralateral dissociation between neural activity and cerebral blood volume during recurrent acute focal neocortical seizures. Epilepsia, 55(9), 1423-1430. View this article in WRRO
- Coupling between gamma-band power and cerebral blood volume during recurrent acute neocortical seizures.. Neuroimage, 97, 62-70. View this article in WRRO
- Abnormalities in whisking behaviour are associated with lesions in brain stem nuclei in a mouse model of amyotrophic lateral sclerosis.. Behav Brain Res, 259, 274-283. View this article in WRRO
- Wide-fieldin vivoneocortical calcium dye imaging using a convection-enhanced loading technique combined with simultaneous multiwavelength imaging of voltage-sensitive dyes and hemodynamic signals. Neurophotonics, 1(1), 015003-015003. View this article in WRRO
- The effects of focal epileptic activity on regional sensory-evoked neurovascular coupling and postictal modulation of bilateral sensory processing.. J Cereb Blood Flow Metab, 33(10), 1595-1604. View this article in WRRO
- The resting-state neurovascular coupling relationship: rapid changes in spontaneous neural activity in the somatosensory cortex are associated with haemodynamic fluctuations that resemble stimulus-evoked haemodynamics.. Eur J Neurosci, 38(6), 2902-2916.
- Functional MRI in conscious rats using a chronically implanted surface coil.. J Magn Reson Imaging, 38(3), 739-744.
- Complex spatiotemporal haemodynamic response following sensory stimulation in the awake rat.. Neuroimage, 66, 1-8.
- Inter-trial variability in sensory-evoked cortical hemodynamic responses: the role of the magnitude of pre-stimulus fluctuations. Frontiers in Neuroenergetics, 4. View this article in WRRO
- Balanced excitation and inhibition: model based analysis of local field potentials.. Neuroimage, 63(1), 81-94.
- Is optical imaging spectroscopy a viable measurement technique for the investigation of the negative BOLD phenomenon? A concurrent optical imaging spectroscopy and fMRI study at high field (7 T).. Neuroimage, 61(1), 10-20.
- Early and late stimulus-evoked cortical hemodynamic responses provide insight into the neurogenic nature of neurovascular coupling. Journal of Cerebral Blood Flow and Metabolism, 32(3), 468-480.
- Neurovascular coupling is brain region-dependent.. Neuroimage, 59(3), 1997-2006.
- Optimised and rapid pre-clinical screening in the SOD1(G93A) transgenic mouse model of amyotrophic lateral sclerosis (ALS).. PLoS One, 6(8), e23244. View this article in WRRO
- Temporal coupling between stimulus-evoked neural activity and hemodynamic responses from individual cortical columns.. Phys Med Biol, 55(8), 2203-2219.
- Negative blood oxygen level dependence in the rat: a model for investigating the role of suppression in neurovascular coupling.. J Neurosci, 30(12), 4285-4294.
- A dynamic model of neurovascular coupling: implications for blood vessel dilation and constriction.. Neuroimage, 52(3), 1135-1147. View this article in WRRO
- Does neural input or processing play a greater role in the magnitude of neuroimaging signals?. Front Neuroenergetics, 2. View this article in WRRO
- Linear superposition of sensory-evoked and ongoing cortical hemodynamics.. Front Neuroenergetics, 2. View this article in WRRO
- Vascular Origins of BOLD and CBV fMRI Signals: Statistical Mapping and Histological Sections Compared.. Open Neuroimag J, 4, 1-8. View this article in WRRO
- Refinement of optical imaging spectroscopy algorithms using concurrent BOLD and CBV fMRI.. Neuroimage, 47(4), 1608-1619.
- Altered neurovascular coupling during information-processing states.. Eur J Neurosci, 27(10), 2758-2772.
- Fine detail of neurovascular coupling revealed by spatiotemporal analysis of the hemodynamic response to single whisker stimulation in rat barrel cortex.. J Neurophysiol, 99(2), 787-798.
- Investigating neural-hemodynamic coupling and the hemodynamic response function in the awake rat.. Neuroimage, 32(1), 33-48.
- Concurrent fMRI and optical measures for the investigation of the hemodynamic response function.. Magn Reson Med, 54(2), 354-365.
- A three-compartment model of the hemodynamic response and oxygen delivery to brain.. Neuroimage, 28(4), 925-939.
- Cocaine administration produces a protracted decoupling of neural and haemodynamic responses to intense sensory stimuli.. Neuroscience, 132(2), 361-374.
- Integration of neural responses originating from different regions of the cortical somatosensory map.. Brain Res, 1030(2), 284-293.
- Optical imaging spectroscopy in the unanaesthetised rat.. J Neurosci Methods, 120(1), 25-34.
- A model of the hemodynamic response and oxygen delivery to brain.. Neuroimage, 16(3 Pt 1), 617-637.
- Hemodynamic response in the unanesthetized rat: intrinsic optical imaging and spectroscopy of the barrel cortex.. J Cereb Blood Flow Metab, 22(6), 670-679.
- Changes in blood flow, oxygenation, and volume following extended stimulation of rodent barrel cortex.. Neuroimage, 15(3), 474-487.
- Increased oxygen consumption following activation of brain: theoretical footnotes using spectroscopic data from barrel cortex.. Neuroimage, 13(6 Pt 1), 975-987.
- Concurrent optical imaging spectroscopy and laser-Doppler flowmetry: the relationship between blood flow, oxygenation, and volume in rodent barrel cortex.. Neuroimage, 13(6 Pt 1), 1002-1015.
- Signal source separation in the analysis of neural activity in brain.. Neuroimage, 13(3), 447-458.
- Spectroscopic analysis of neural activity in brain: increased oxygen consumption following activation of barrel cortex.. Neuroimage, 12(6), 664-675.
- Spectroscopic investigation of reflectance changes in the barrel cortex following whisker stimulation.. Adv Exp Med Biol, 454, 139-148.
- An evaluation of linear model analysis techniques for processing images of microcirculation activity.. Neuroimage, 7(1), 49-71.
- Optical triggered seizures using a caged 4-Aminopyridine. Frontiers in Neuroscience, 9. View this article in WRRO
Conference proceedings papers
- Spatiotemporal complexity in the haemodynamic response to somatosensory stimulation in the un-anaesthetized rat. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol. 29 (pp S105-S105)
- Functional magnetic resonance imaging in un-anaesthetized rats using a chronically implanted surface coil. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol. 29 (pp S606-S607)
- A mathematical model of the neurovascular coupling suggesting both vasodilation and vasoconstriction. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol. 29 (pp S19-S20)
All publications
Journal articles
- Bidirectional alterations in brain temperature profoundly modulate spatiotemporal neurovascular responses in-vivo. Communications Biology, 6.
- The reversal characteristics of GABAergic neurons: a neurovascular model. Journal of Biomechanical Engineering, 145(3). View this article in WRRO
- How does alzheimer’s disease, atherosclerosis and comorbid alzheimer’s disease and atherosclerosis impact neurovascular function?. Alzheimer's & Dementia, 18(S6).
- Validating layer-specific VASO across species.. Neuroimage, 237.
- Preclinical models of disease and multimorbidity with focus upon cardiovascular disease and dementia. Mechanisms of Ageing and Development, 192, 111361-111361.
- Enhanced cerebral blood volume under normobaric hyperoxia in the J20-hAPP mouse model of Alzheimer’s disease. Scientific Reports, 10(1). View this article in WRRO
- Acute effects of systemic inflammation upon the neuro-glial-vascular unit and cerebrovascular function.. Brain, Behavior, & Immunity - Health, 5. View this article in WRRO
- Key Aspects of Neurovascular Control Mediated by Specific Populations of Inhibitory Cortical Interneurons. Cerebral Cortex, 30(4), 2452-2464. View this article in WRRO
- Neurovascular coupling preserved in a chronic mouse model of Alzheimer’s disease: Methodology is critical.. Journal of Cerebral Blood Flow and Metabolism. View this article in WRRO
- The time course of recognition memory impairment and glial pathology in the hAPP-J20 mouse model of Alzheimer’s disease. Journal of Alzheimer's disease : JAD. View this article in WRRO
- Neurovascular Dysfunction in Vascular Dementia, Alzheimer’s and Atherosclerosis. BMC Neuroscience, 19. View this article in WRRO
- Physiological and pathological brain activation in the anesthetized rat produces hemodynamic-dependent cortical temperature increases that can confound the BOLD fMRI signal.. Frontiers in Neuroscience, 12. View this article in WRRO
- Seizure epicenter depth and translaminar field potential synchrony underlie complex variations in tissue oxygenation during ictal initiation. NeuroImage, 171, 165-175. View this article in WRRO
- Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology. Clinical Science, 132(8), 851-868. View this article in WRRO
- Review: Neuropathology and behavioural features of transgenic murine models of Alzheimer's disease. Neuropathology and Applied Neurobiology, 43(7), 553-570. View this article in WRRO
- The neurogenesis of P1 and N1: A concurrent EEG/LFP study. NeuroImage, 146, 575-588. View this article in WRRO
- Decreased haemodynamic response and decoupling of cortical gamma-band activity and tissue oxygen perfusion after striatal interleukin-1 injection. Journal of Neuroinflammation, 13(1), 195-195. View this article in WRRO
- A novel method for classifying cortical state to identify the accompanying changes in cerebral haemodynamics. Journal of Neuroscience Methods, 267, 21-34. View this article in WRRO
- Comparison of stimulus-evoked cerebral hemodynamics in the awake mouse and under a novel anesthetic regime. Scientific Reports, 5. View this article in WRRO
- LRP-1-mediated intracellular antibody delivery to the Central Nervous System. Scientific Reports, 5, 11990-11990. View this article in WRRO
- Long-Latency Reductions in Gamma Power Predict Hemodynamic Changes That Underlie the Negative BOLD Signal. Journal of Neuroscience, 35(11), 4641-4656. View this article in WRRO
- Erratum: Corrigendum: Comparison of stimulus-evoked cerebral hemodynamics in the awake mouse and under a novel anesthetic regime. Scientific Reports, 5(1).
- Contralateral dissociation between neural activity and cerebral blood volume during recurrent acute focal neocortical seizures. Epilepsia, 55(9), 1423-1430. View this article in WRRO
- Coupling between gamma-band power and cerebral blood volume during recurrent acute neocortical seizures.. Neuroimage, 97, 62-70. View this article in WRRO
- Abnormalities in whisking behaviour are associated with lesions in brain stem nuclei in a mouse model of amyotrophic lateral sclerosis.. Behav Brain Res, 259, 274-283. View this article in WRRO
- Wide-fieldin vivoneocortical calcium dye imaging using a convection-enhanced loading technique combined with simultaneous multiwavelength imaging of voltage-sensitive dyes and hemodynamic signals. Neurophotonics, 1(1), 015003-015003. View this article in WRRO
- The effects of focal epileptic activity on regional sensory-evoked neurovascular coupling and postictal modulation of bilateral sensory processing.. J Cereb Blood Flow Metab, 33(10), 1595-1604. View this article in WRRO
- The resting-state neurovascular coupling relationship: rapid changes in spontaneous neural activity in the somatosensory cortex are associated with haemodynamic fluctuations that resemble stimulus-evoked haemodynamics.. Eur J Neurosci, 38(6), 2902-2916.
- Functional MRI in conscious rats using a chronically implanted surface coil.. J Magn Reson Imaging, 38(3), 739-744.
- Kinetic modeling of hyperpolarized (13)C pyruvate metabolism in tumors using a measured arterial input function.. Magn Reson Med, 70(4), 943-953.
- Complex spatiotemporal haemodynamic response following sensory stimulation in the awake rat.. Neuroimage, 66, 1-8.
- Inter-trial variability in sensory-evoked cortical hemodynamic responses: the role of the magnitude of pre-stimulus fluctuations. Frontiers in Neuroenergetics, 4. View this article in WRRO
- Balanced excitation and inhibition: model based analysis of local field potentials.. Neuroimage, 63(1), 81-94.
- Is optical imaging spectroscopy a viable measurement technique for the investigation of the negative BOLD phenomenon? A concurrent optical imaging spectroscopy and fMRI study at high field (7 T).. Neuroimage, 61(1), 10-20.
- Early and late stimulus-evoked cortical hemodynamic responses provide insight into the neurogenic nature of neurovascular coupling. Journal of Cerebral Blood Flow and Metabolism, 32(3), 468-480.
- Early and late stimulus-evoked cortical hemodynamic responses provide insight into the neurogenic nature of neurovascular coupling.. J Cereb Blood Flow Metab, 32(3), 468-480.
- Neurovascular coupling is brain region-dependent.. Neuroimage, 59(3), 1997-2006.
- Optimised and rapid pre-clinical screening in the SOD1(G93A) transgenic mouse model of amyotrophic lateral sclerosis (ALS).. PLoS One, 6(8), e23244. View this article in WRRO
- Temporal coupling between stimulus-evoked neural activity and hemodynamic responses from individual cortical columns.. Phys Med Biol, 55(8), 2203-2219.
- Negative blood oxygen level dependence in the rat: a model for investigating the role of suppression in neurovascular coupling.. J Neurosci, 30(12), 4285-4294.
- A dynamic model of neurovascular coupling: implications for blood vessel dilation and constriction.. Neuroimage, 52(3), 1135-1147. View this article in WRRO
- Does neural input or processing play a greater role in the magnitude of neuroimaging signals?. Front Neuroenergetics, 2. View this article in WRRO
- Linear superposition of sensory-evoked and ongoing cortical hemodynamics.. Front Neuroenergetics, 2. View this article in WRRO
- Vascular Origins of BOLD and CBV fMRI Signals: Statistical Mapping and Histological Sections Compared.. Open Neuroimag J, 4, 1-8. View this article in WRRO
- Refinement of optical imaging spectroscopy algorithms using concurrent BOLD and CBV fMRI.. Neuroimage, 47(4), 1608-1619.
- Altered neurovascular coupling during information-processing states.. Eur J Neurosci, 27(10), 2758-2772.
- Fine detail of neurovascular coupling revealed by spatiotemporal analysis of the hemodynamic response to single whisker stimulation in rat barrel cortex.. J Neurophysiol, 99(2), 787-798.
- Preservation of visual cortical function following retinal pigment epithelium transplantation in the RCS rat using optical imaging techniques. EUR J NEUROSCI, 25(7), 1940-1948.
- Investigating neural-hemodynamic coupling and the hemodynamic response function in the awake rat.. Neuroimage, 32(1), 33-48.
- Neurovascular coupling investigated with two-dimensional optical imaging spectroscopy in rat whisker barrel cortex.. Eur J Neurosci, 22(7), 1655-1666.
- The effect of hypercapnia on the neural and hemodynamic responses to somatosensory stimulation.. Neuroimage, 27(3), 609-623. View this article in WRRO
- Concurrent fMRI and optical measures for the investigation of the hemodynamic response function.. Magn Reson Med, 54(2), 354-365.
- Long duration stimuli and nonlinearities in the neural-haemodynamic coupling.. J Cereb Blood Flow Metab, 25(5), 651-661.
- k-space correction of eddy-current-induced distortions in diffusion-weighted echo-planar imaging.. Magn Reson Med, 53(5), 1103-1111.
- Further nonlinearities in neurovascular coupling in rodent barrel cortex.. Neuroimage, 24(2), 565-574.
- A three-compartment model of the hemodynamic response and oxygen delivery to brain.. Neuroimage, 28(4), 925-939.
- Cocaine administration produces a protracted decoupling of neural and haemodynamic responses to intense sensory stimuli.. Neuroscience, 132(2), 361-374.
- Integration of neural responses originating from different regions of the cortical somatosensory map.. Brain Res, 1030(2), 284-293.
- Haemodynamic responses to sensory stimulation are enhanced following acute cocaine administration.. Neuroimage, 22(4), 1744-1753.
- The hemodynamic impulse response to a single neural event.. J Cereb Blood Flow Metab, 23(5), 546-555.
- Optical imaging spectroscopy in the unanaesthetised rat.. J Neurosci Methods, 120(1), 25-34.
- A model of the hemodynamic response and oxygen delivery to brain.. Neuroimage, 16(3 Pt 1), 617-637.
- Hemodynamic response in the unanesthetized rat: intrinsic optical imaging and spectroscopy of the barrel cortex.. J Cereb Blood Flow Metab, 22(6), 670-679.
- Changes in blood flow, oxygenation, and volume following extended stimulation of rodent barrel cortex.. Neuroimage, 15(3), 474-487.
- Increased oxygen consumption following activation of brain: theoretical footnotes using spectroscopic data from barrel cortex.. Neuroimage, 13(6 Pt 1), 975-987.
- Concurrent optical imaging spectroscopy and laser-Doppler flowmetry: the relationship between blood flow, oxygenation, and volume in rodent barrel cortex.. Neuroimage, 13(6 Pt 1), 1002-1015.
- Visual cortical function in non-dystrophic and dystrophic RCS rats as revealed by intrinsic optical imaging.. INVEST OPHTH VIS SCI, 42(4), S787-S787.
- Spectroscopic analysis of neural activity in brain: Increased oxygen consumption following activation of barrel cortex (vol 12, pg 664, 2000). NEUROIMAGE, 13(3), 540-543.
- Signal source separation in the analysis of neural activity in brain.. Neuroimage, 13(3), 447-458.
- Catheter tracking for MR fluoroscopy: Design of a transmit/receive coil for use with a nasogastric tube. Journal of Magnetic Resonance Imaging, 13(1), 127-130.
- Design and initial evaluation of a low-cost 3-Tesla research system for combined optical and functional MR imaging with interventional capability.. J Magn Reson Imaging, 13(1), 87-92.
- Spectroscopic analysis of neural activity in brain: increased oxygen consumption following activation of barrel cortex.. Neuroimage, 12(6), 664-675.
- Pseudo-random procedures for rapid presentation rates using optical imaging and spectroscopy.. Neuroreport, 11(10), 2247-2252.
- Spectroscopic analysis of the action of 7-NI on the coupling of neural activity and the haemodynamic response in barrel cortex.. EUR J NEUROSCI, 12, 425-425.
- Spectroscopic analysis of changes in remitted illumination: the response to increased neural activity in brain.. Neuroimage, 10(3 Pt 1), 304-326.
- The spatio-temporal characteristics of the response to increased neural activity. NeuroImage, 9(6 PART II).
- Spectroscopic investigation of reflectance changes in the barrel cortex following whisker stimulation.. Adv Exp Med Biol, 454, 139-148.
- An evaluation of linear model analysis techniques for processing images of microcirculation activity.. Neuroimage, 7(1), 49-71.
- The effects of locomotion on sensory-evoked haemodynamic responses in the cortex of awake mice. Scientific Reports.
- Optical triggered seizures using a caged 4-Aminopyridine. Frontiers in Neuroscience, 9. View this article in WRRO
- Assessment of Neurovascular Coupling & Cortical Spreading Depression in Mixed Models of Atherosclerosis & Alzheimer’s Disease.
- The time course of recognition memory impairment and glial pathology in the hAPP-J20 mouse model of Alzheimer's disease..
- Neurovascular coupling preserved in a chronic mouse model of Alzheimer’s disease: Methodology is critical.
- Neurovascular Function in a Novel Model of Experimental Atherosclerosis.
- Acute effects of systemic inflammation upon neurovascular unit and cerebrovascular function..
- Validating layer-specific VASO across species.
- Assessment of neurovascular coupling
and cortical spreading depression in
mixed mouse models of atherosclerosis
and Alzheimer’s disease. eLife.
Chapters
- Voltage Sensitive Dye Imaging, Intrinsic Optical Signals, Encyclopedia of Computational Neuroscience (pp. 3628-3631).
- Voltage Sensitive Dye Imaging, Intrinsic Optical Signals, Encyclopedia of Computational Neuroscience (pp. 3144-3147). Springer New York
- Vagus Nerve Stimulation, Encyclopedia of Computational Neuroscience (pp. 3025-3025). Springer New York
- Voltage-Sensitive Dye Imaging, Intrinsic Optical Signals, Encyclopedia of Computational Neuroscience (pp. 1-4). Springer New York
- Simultaneous Functional Magnetic Resonance and Two-Dimensional Optical Imaging Spectroscopy, Neurovascular Coupling Methods (pp. 3-20). Springer New York
Conference proceedings papers
- The influence of mild hypercapnia on brain intracellular pH, phosphate metabolites and cerebral blood flow: A multi-nuclear (1H/31P) MR study at 7T. Proc. Intl. Soc. Mag. Reson. Med. (2017), 22 April 2017 - 27 April 2017.
- Spatiotemporal complexity in the haemodynamic response to somatosensory stimulation in the un-anaesthetized rat. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol. 29 (pp S105-S105)
- Functional magnetic resonance imaging in un-anaesthetized rats using a chronically implanted surface coil. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol. 29 (pp S606-S607)
- A mathematical model of the neurovascular coupling suggesting both vasodilation and vasoconstriction. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol. 29 (pp S19-S20)
- Concurrent optical imaging spectroscopy, laser Doppler flowmetry and magnetic resonance imaging in the investigation of the relative intra and extra vascular contributions to the BOLD signal. Biomedical Topical Meeting, 2004.
- Optical imaging of visual cortex in unanaesthetised rat. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol. 43 (pp U1339-U1339)
- Analysis of optical imaging data using weak models and ICA. ADVANCES IN INDEPENDENT COMPONENT ANALYSIS (pp 217-233)
- Optical imaging of visual cortex in congenic and dystrophic royal college of surgeons rats. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol. 40(4) (pp S124-S124)
Preprints
- Nitric oxide is not responsible for the initial sensory-induced neurovascular coupling response in mouse cortex, bioRxiv.
- Bidirectional alterations in brain temperature profoundly modulate spatiotemporal neurovascular responses in-vivo: Implications for theragnostics, Cold Spring Harbor Laboratory.
- The effects of locomotion on sensory-evoked haemodynamic responses in the cortex of awake mice, Cold Spring Harbor Laboratory.
- Acute effects of systemic inflammation upon the neuro-glial-vascular unit and cerebrovascular function., Research Square Platform LLC.
- Enhanced Cerebral Blood Volume under Normobaric Hyperoxia in the J20-hAPP Mouse Model of Alzheimer’s Disease.
- Physiological and pathological brain activation in the anesthetized rat produces hemodynamic-dependent cortical temperature increases that can confound the BOLD fMRI signal, Cold Spring Harbor Laboratory.
- Seizure epicenter depth and translaminar field potential synchrony underlie complex variations in tissue oxygenation during ictal initiation., Cold Spring Harbor Laboratory.
- Bidirectional alterations in brain temperature profoundly modulate spatiotemporal neurovascular responses in-vivo. Communications Biology, 6.
- Research group
-
Part of the Neuroscience and Cognition Group
Postdoctoral Researcher
-
Dr Osman Shabir – Investigating the links between Atherosclerosis and Dementia
Research Associates
- Beth Eyre Llywelyn Lee
Postgraduate students
-
Naomi King - "Developing chronic implants for the treatment of Alzheimer's disease in pre-clinical models"
-
Shannon O'Connor - "Neurotransmitters, brain blood flow and functional brain imaging signals"
-
Rahul Sidhu - "Two diseases, one brain: The effects of cardiovascular disease on the speed, progression and severity of Alzheimer's Disease"
-
Runchong Wang - "Neuronal coupling across spatiotemporal scales and dimensions of cortical population activity"
-
Marilina Douloudi
-
- Grants
-
Recent Grants:
- 2023-2026 Medical Research Council project grant - Massaging brain vessels with vasomotion: Targeting the vasculature to alter disease progression in mouse models of dementia. Dr Jason Berwick and Dr Clare Howarth (Joint PI’s). Dr Chris Martin and Dr Julie Simpson. £1.24M full fec.
- 2021-2024 Sheffield Neuroscience Institute PhD studentship award : Cortical hyperexcitability as a novel therapeutic target in neurodegenerative disease : Dr Richard Mead (Primary Supervisor), Dr Matthew Livesey, Dr Clare Howarth, Dr Jason Berwick and Dr Jodie Stephenson (Co-supervisors). - £140K.
- 2021-2024 Sheffield Neuroscience Institute PhD studentship award : Developing chronic implants for the treatment of Alzheimer’s disease in pre-clinical models. Dr Jason Berwick (Primary Supervisor), Dr Clare Howarth and Professor Ivan Minev (Co-supervisors). - £80K
- 2022-2025 MRC DiMen DTP PhD studentship award : Two diseases, one brain: The effects of cardiovascular disease on the speed, progression and severity of Alzheimer’s Disease. Dr Clare Howarth (Primary Supervisor), Dr Jason Berwick and Professor Sheila Francis (Co-supervisors) - £80K.
- 2020-2023 British Heart Foundation Project grant: Atherosclerosis, the brain and vascular dementia – the role of inflammation in neurovascular function. Professor Sheila Francis (PI),Dr Jason Berwick (CO-I), Dr Clare Howarth, Professor Stuart Allan, Dr Emmanuel Pinteaux: £256K
- 2019-2022 Battelle PhD studentship: Understanding neurovascular breakdown in the APP/PS1 mouse. Berwick J and Howarth (Joint PI’s), Vazquez A (CO-I) - £137K
Past Grants:
- 2016 MRC-KHIDI UK-KOREA PARTNERING AWARDS Title: Integrating multimodal imaging technologies to investigate neurovascular dysfunction in neurological disorders Sheffield University Team: Dr Jason Berwick (PI), Dr Luke Boorman, Dr Sam Harris, Dr Paul Sharp Sungkyunkwan University Team: Professor Minah Suh (PI). Dr Eunha Baeg, Dr Chaejeong Heo, Dr Sohee Lee. Total value: £20K
- 2016-2018. Brain Research New Zealand. Dysfunctional Neurovascular Coupling: A precursor to Alzheimer’s? David T (PI), Berwick J (CO-I). $180K NZ Dollar.
- 2015 FRIENZ study tour of New Zealand – ‘Living a Long and Healthy Life. ~£10K
- 2015-2018 Epilepsy Research UK project grant. How activation of sensory regions can promote propagation of adjacent focal neocortical seizures. Berwick J (PI), Harris S, Schwartz T, Overton PG, Kennerley A, Zheng Y. £147K
- 2015-2018 Medical Research Council. Investigating the thermoregulatory role of neurovascular coupling and the anti-epileptogenic and neuroprotective effects of focal cerebral cooling. Berwick J (PI), Harris S, Martin C, Redgrave P, Boorman L, Kennerley A. ~£558K Full Fec
- 2014-2016 Interdisciplinary Research Grant Alzheimer’s Research UK. Neurovascular dysfunction in Alzheimer’s disease: the search for early biomarkers. Berwick J (PI), Wharton S, Heath P. ~£507K full fec
- 2015-2019 Wellcome Trust Health Innovation Challenge Fund – Round 8. GOLD imaging in acute stroke: further technology development incorporating a perfluorocarbon oxygen carrier. Muir K (PI), Santosh C (PI), Macrae IM, Deuchar G, Berwick J (CO-I), Kennerley AJ. £1.79M full fec (£120K to Sheffield)
- 2013-2016 Biotechnology and biological sciences research council. Understanding neural excitation and inhibition: implications for the interpretation of extracellular field potentials and neurovascular coupling. Zheng Y (PI), Berwick J, Jones M, Billings S, Coca D, Milne E, Redgrave P. ~£850K full fec
- 2011-2014 Medical Research Council. The neurophysiological basis of negative BOLD signals – Berwick J (PI), Jones M, Kennerley A, Boorman L, Martin C, Redgrave P, Zheng Y. £655K full fec
- 2011-2014 Wellcome Trust. Understanding Epilepsy in the active brain - Berwick J (PI), Overton PG, Schwartz T, Kennerley A, Ma H, Zhao M. ~£519K full fec
- 2009- 2012 EPSRC. "Engineering virus-like nanoparticles for targeting the central nervous system". G Battaglia (PI), S P. Armes, M. Azzouz, O. Bandmann, J. Berwick, P.G. Ince , A.J. Kennerley, M. Jones, R. Golestanian, R. Hose, R. Mead, K. Ning, A.J. Ryan, P. Shaw, R. Smallwood, D. Walker & Y. Zheng. £ 2,060,808;
- 2007 – 2010 Medical Research Council New Investigator Award entitled ‘Neurovascular Coupling under the microscope’ – Principal Investigator £415K
- Teaching activities
-
Teach across all Clinical/Neuro undergraduate streams including :
- PSY1003: Neuroscience and Clinical Psychology
- PSY2003: Neuroscience and Clinical Psychology II
- PSY303: Neural Basis of Learning and Memory
- PSY331- Extended essay
- PSY346 - Research project Teach across masters courses in Cognitive neuroscience
- PSY6306 - Fundamentals of Neuroscience
- PSY6424 - Neuroimaging 2
- Professional activities and memberships
-
- Assistant Faculty Director of Research and Innovation (2021-present)
- BBRSC Grant Panel member (2017-2023)
- Member of Sheffield Neuroscience Executive Board (2019-present)