Dr Jason Berwick

PhD, Bsc(Hons)

Department of Psychology

Reader in Neurophysiology

Assistant Faculty Director of Research and Innovation

j.berwick@sheffield.ac.uk
+44 114 222 6597

+44 114 222 6597 (fax)

Cathedral Court

Full contact details

Dr Jason Berwick
Department of Psychology
Cathedral Court
1 Vicar Lane
Sheffield
S1 2LT

Profile

I joined the Department of Psychology in 1996 as a PhD student in the laboratory of Professor John Mayhew. Our research uses multimodal imaging and electrophysiological techniques to measure a mechanism in the brain called Neurovascular coupling (NVC). This mechanism provides the image contrast for modern neuroimaging technologies such as functional magnetic resonance imaging (fMRI) and the early focus of the research was to understand NVC in order to provide a better understanding and interpretation of fMRI signals.

My position was made permanent in 2007 and our research has now expanded to investigate in neurodegenerations with a particular focus on Alzheimer’s disease and focal cortical epilepsy. Our laboratory is focussed on not only understanding NVC decline in disease but also in the development of novel therapies that target the cerebrovascular system to slow down or halt disease progression.

I am in the privileged position in that my job is also my hobby and I am passionate about encouraging students to experience research and to help develop the next generation of scientists.

Qualifications

Bsc (Hons) Anatomy and Cell Biology, University of Sheffield.
PhD Neuroscience, University of Sheffield

Research interests

Neurovascular coupling is a mechanism that ensures active regions of the brain are supplied with enough oxygen and glucose to function properly. Although first discovered over 130 years ago, to this day we still do not have a complete understanding about how neurovascular coupling works. Our laboratory uses multimodal neuroimaging and electrophysiological techniques to measure and understand neurovascular coupling in normal function, how it goes wrong in disease and importantly to develop new therapies based on enhancing/restoring cerebrovascular function.

Current projects include:

Neurovascular coupling and breakdown in Alzheimer’s Disease
Neurovascular coupling in Focal Cortical Epilepsy
Interpretation of the negative BOLD fMRI signal
The role of temperature in Neurovascular coupling.
The interaction between Atherosclerosis and Alzheimer’s Disease

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Shabir O, Sharp P, Rebollar MA, Boorman L, Howarth C, Wharton SB, Francis SE & Berwick J (2020) Enhanced cerebral blood volume under normobaric hyperoxia in the J20-hAPP mouse model of Alzheimer’s disease. Scientific Reports, 10(1). View this article in WRRO
Lee L, Boorman L, Glendenning E, Christmas C, Sharp P, Redgrave P, Shabir O, Bracci E, Berwick J & Howarth C (2020) Key Aspects of Neurovascular Control Mediated by Specific Populations of Inhibitory Cortical Interneurons. Cerebral Cortex, 30(4), 2452-2464. View this article in WRRO
Sharp P, Ameen-Ali K, Boorman L, Harris S, Wharton S, Howarth C, Shabir O, Redgrave P & Berwick J (2019) Neurovascular coupling preserved in a chronic mouse model of Alzheimer’s disease: Methodology is critical.. Journal of Cerebral Blood Flow and Metabolism. View this article in WRRO
Ameen-Ali K, Simpson J, Wharton S, Heath P, Sharp P, Brezzo G & Berwick J (2019) The time course of recognition memory impairment and glial pathology in the hAPP-J20 mouse model of Alzheimer’s disease. Journal of Alzheimer's disease : JAD. View this article in WRRO
Shabir O, Berwick J & Francis S (2018) Neurovascular Dysfunction in Vascular Dementia, Alzheimer’s and Atherosclerosis. BMC Neuroscience, 19. View this article in WRRO
Harris S, Boorman L, Das D, Kennerley A, Sharp P, Martin C, Redgrave P, Schwartz T & Berwick J (2018) Physiological and pathological brain activation in the anesthetized rat produces hemodynamic-dependent cortical temperature increases that can confound the BOLD fMRI signal.. Frontiers in Neuroscience, 12. View this article in WRRO
Harris SS, Boorman L, Kennerley AJ, Sharp PS, Redgrave P, Martin C, Schwartz TH & Berwick J (2018) Seizure epicenter depth and translaminar field potential synchrony underlie complex variations in tissue oxygenation during ictal initiation. NeuroImage, 171, 165-175. View this article in WRRO
Horsburgh K, Wardlaw JM, van Agtmael T, Allan SM, Ashford MLJ, Bath PM, Brown R, Berwick J, Cader MZ, Carare RO , Davis JB et al (2018) Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology. Clinical Science, 132(8), 851-868. View this article in WRRO
Ameen-Ali KE, Wharton SB, Simpson JE, Heath PR, Sharp P & Berwick J (2017) Review: Neuropathology and behavioural features of transgenic murine models of Alzheimer's disease. Neuropathology and Applied Neurobiology, 43(7), 553-570. View this article in WRRO
Bray N, Burrows FE, Jones M, Berwick J, Allan SM & Schiessl I (2016) Decreased haemodynamic response and decoupling of cortical gamma-band activity and tissue oxygen perfusion after striatal interleukin-1 injection. Journal of Neuroinflammation, 13(1), 195-195. View this article in WRRO
Sharp PS, Shaw K, Boorman L, Harris S, Kennerley A, Azzouz M & Berwick J (2015) Comparison of stimulus-evoked cerebral hemodynamics in the awake mouse and under a novel anesthetic regime. Scientific Reports, 5. View this article in WRRO
Tian X, Nyberg S, S. Sharp P, Madsen J, Daneshpour N, Armes SP, Berwick J, Azzouz M, Shaw P, Abbott NJ & Battaglia G (2015) LRP-1-mediated intracellular antibody delivery to the Central Nervous System. Scientific Reports, 5, 11990-11990. View this article in WRRO
Boorman L, Harris S, Bruyns-Haylett M, Kennerley A, Zheng Y, Martin CJ, Jones M, Redgrave P & Berwick J (2015) Long-Latency Reductions in Gamma Power Predict Hemodynamic Changes That Underlie the Negative BOLD Signal. Journal of Neuroscience, 35(11), 4641-4656. View this article in WRRO
Harris S, Boorman L, Bruyns-Haylett M, Kennerley A, Ma H, Zhao M, Overton PG, Schwartz TH & Berwick J (2014) Contralateral dissociation between neural activity and cerebral blood volume during recurrent acute focal neocortical seizures. Epilepsia, 55(9), 1423-1430. View this article in WRRO
Harris S, Ma H, Zhao M, Boorman L, Zheng Y, Kennerley A, Bruyns-Haylett M, Overton PG, Berwick J & Schwartz TH (2014) Coupling between gamma-band power and cerebral blood volume during recurrent acute neocortical seizures.. Neuroimage, 97, 62-70. View this article in WRRO
Grant RA, Sharp PS, Kennerley AJ, Berwick J, Grierson A, Ramesh T & Prescott TJ (2014) Abnormalities in whisking behaviour are associated with lesions in brain stem nuclei in a mouse model of amyotrophic lateral sclerosis.. Behav Brain Res, 259, 274-283. View this article in WRRO
Ma H, Harris S, Rahmani R, Lacefield CO, Zhao M, Daniel AGS, Zhou Z, Bruno RM, Berwick J & Schwartz TH (2014) Wide-fieldin vivoneocortical calcium dye imaging using a convection-enhanced loading technique combined with simultaneous multiwavelength imaging of voltage-sensitive dyes and hemodynamic signals. Neurophotonics, 1(1), 015003-015003. View this article in WRRO
Harris S, Bruyns-Haylett M, Kennerley A, Boorman L, Overton PG, Ma H, Zhao M, Schwartz TH & Berwick J (2013) The effects of focal epileptic activity on regional sensory-evoked neurovascular coupling and postictal modulation of bilateral sensory processing.. J Cereb Blood Flow Metab, 33(10), 1595-1604. View this article in WRRO
Bruyns-Haylett M, Harris S, Boorman L, Zheng Y, Berwick J & Jones M (2013) The resting-state neurovascular coupling relationship: rapid changes in spontaneous neural activity in the somatosensory cortex are associated with haemodynamic fluctuations that resemble stimulus-evoked haemodynamics.. Eur J Neurosci, 38(6), 2902-2916.
Martin CJ, Kennerley AJ, Berwick J, Port M & Mayhew JEW (2013) Functional MRI in conscious rats using a chronically implanted surface coil.. J Magn Reson Imaging, 38(3), 739-744.
Martin C, Zheng Y, Sibson NR, Mayhew JEW & Berwick J (2013) Complex spatiotemporal haemodynamic response following sensory stimulation in the awake rat.. Neuroimage, 66, 1-8.
Saka M, Berwick J & Jones M (2012) Inter-trial variability in sensory-evoked cortical hemodynamic responses: the role of the magnitude of pre-stimulus fluctuations. Frontiers in Neuroenergetics, 4. View this article in WRRO
Zheng Y, Luo JJ, Harris S, Kennerley A, Berwick J, Billings SA & Mayhew J (2012) Balanced excitation and inhibition: model based analysis of local field potentials.. Neuroimage, 63(1), 81-94.
Kennerley AJ, Mayhew JE, Boorman L, Zheng Y & Berwick J (2012) Is optical imaging spectroscopy a viable measurement technique for the investigation of the negative BOLD phenomenon? A concurrent optical imaging spectroscopy and fMRI study at high field (7 T).. Neuroimage, 61(1), 10-20.
Kennerley AJ, Harris S, Bruyns-Haylett M, Boorman L, Zheng Y, Jones M & Berwick J (2012) Early and late stimulus-evoked cortical hemodynamic responses provide insight into the neurogenic nature of neurovascular coupling. Journal of Cerebral Blood Flow and Metabolism, 32(3), 468-480.
Devonshire IM, Papadakis NG, Port M, Berwick J, Kennerley AJ, Mayhew JEW & Overton PG (2012) Neurovascular coupling is brain region-dependent.. Neuroimage, 59(3), 1997-2006.
Mead RJ, Bennett EJ, Kennerley AJ, Sharp P, Sunyach C, Kasher P, Berwick J, Pettmann B, Battaglia G, Azzouz M , Grierson A et al (2011) Optimised and rapid pre-clinical screening in the SOD1(G93A) transgenic mouse model of amyotrophic lateral sclerosis (ALS).. PLoS One, 6(8), e23244. View this article in WRRO
Bruyns-Haylett M, Zheng Y, Berwick J & Jones M (2010) Temporal coupling between stimulus-evoked neural activity and hemodynamic responses from individual cortical columns.. Phys Med Biol, 55(8), 2203-2219.
Boorman L, Kennerley AJ, Johnston D, Jones M, Zheng Y, Redgrave P & Berwick J (2010) Negative blood oxygen level dependence in the rat: a model for investigating the role of suppression in neurovascular coupling.. J Neurosci, 30(12), 4285-4294.
Zheng Y, Pan Y, Harris S, Billings S, Coca D, Berwick J, Jones M, Kennerley A, Johnston D, Martin C , Devonshire IM et al (2010) A dynamic model of neurovascular coupling: implications for blood vessel dilation and constriction.. Neuroimage, 52(3), 1135-1147. View this article in WRRO
Harris S, Jones M, Zheng Y & Berwick J (2010) Does neural input or processing play a greater role in the magnitude of neuroimaging signals?. Front Neuroenergetics, 2. View this article in WRRO
Saka M, Berwick J & Jones M (2010) Linear superposition of sensory-evoked and ongoing cortical hemodynamics.. Front Neuroenergetics, 2. View this article in WRRO
Kennerley AJ, Mayhew JE, Redgrave P & Berwick J (2010) Vascular Origins of BOLD and CBV fMRI Signals: Statistical Mapping and Histological Sections Compared.. Open Neuroimag J, 4, 1-8. View this article in WRRO
Kennerley AJ, Berwick J, Martindale J, Johnston D, Zheng Y & Mayhew JE (2009) Refinement of optical imaging spectroscopy algorithms using concurrent BOLD and CBV fMRI.. Neuroimage, 47(4), 1608-1619.
Jones M, Devonshire IM, Berwick J, Martin C, Redgrave P & Mayhew J (2008) Altered neurovascular coupling during information-processing states.. Eur J Neurosci, 27(10), 2758-2772.
Berwick J, Johnston D, Jones M, Martindale J, Martin C, Kennerley AJ, Redgrave P & Mayhew JEW (2008) Fine detail of neurovascular coupling revealed by spatiotemporal analysis of the hemodynamic response to single whisker stimulation in rat barrel cortex.. J Neurophysiol, 99(2), 787-798.
Martin C, Martindale J, Berwick J & Mayhew J (2006) Investigating neural-hemodynamic coupling and the hemodynamic response function in the awake rat.. Neuroimage, 32(1), 33-48.
Kennerley AJ, Berwick J, Martindale J, Johnston D, Papadakis N & Mayhew JE (2005) Concurrent fMRI and optical measures for the investigation of the hemodynamic response function.. Magn Reson Med, 54(2), 354-365.
Zheng Y, Johnston D, Berwick J, Chen D, Billings S & Mayhew J (2005) A three-compartment model of the hemodynamic response and oxygen delivery to brain.. Neuroimage, 28(4), 925-939.
Berwick J, Devonshire IM, Martindale AJ, Johnston D, Zheng Y, Kennerley AJ, Overton PG & Mayhew JEW (2005) Cocaine administration produces a protracted decoupling of neural and haemodynamic responses to intense sensory stimuli.. Neuroscience, 132(2), 361-374.
Berwick J, Redgrave P, Jones M, Hewson-Stoate N, Martindale J, Johnston D & Mayhew JEW (2004) Integration of neural responses originating from different regions of the cortical somatosensory map.. Brain Res, 1030(2), 284-293.
Martin C, Berwick J, Johnston D, Zheng Y, Martindale J, Port M, Redgrave P & Mayhew J (2002) Optical imaging spectroscopy in the unanaesthetised rat.. J Neurosci Methods, 120(1), 25-34.
Zheng Y, Martindale J, Johnston D, Jones M, Berwick J & Mayhew J (2002) A model of the hemodynamic response and oxygen delivery to brain.. Neuroimage, 16(3 Pt 1), 617-637.
Berwick J, Martin C, Martindale J, Jones M, Johnston D, Zheng Y, Redgrave P & Mayhew J (2002) Hemodynamic response in the unanesthetized rat: intrinsic optical imaging and spectroscopy of the barrel cortex.. J Cereb Blood Flow Metab, 22(6), 670-679.
Jones M, Berwick J & Mayhew J (2002) Changes in blood flow, oxygenation, and volume following extended stimulation of rodent barrel cortex.. Neuroimage, 15(3), 474-487.
Mayhew J, Johnston D, Martindale J, Jones M, Berwick J & Zheng Y (2001) Increased oxygen consumption following activation of brain: theoretical footnotes using spectroscopic data from barrel cortex.. Neuroimage, 13(6 Pt 1), 975-987.
Jones M, Berwick J, Johnston D & Mayhew J (2001) Concurrent optical imaging spectroscopy and laser-Doppler flowmetry: the relationship between blood flow, oxygenation, and volume in rodent barrel cortex.. Neuroimage, 13(6 Pt 1), 1002-1015.
Zheng Y, Johnston D, Berwick J & Mayhew J (2001) Signal source separation in the analysis of neural activity in brain.. Neuroimage, 13(3), 447-458.
Mayhew J, Johnston D, Berwick J, Jones M, Coffey P & Zheng Y (2000) Spectroscopic analysis of neural activity in brain: increased oxygen consumption following activation of barrel cortex.. Neuroimage, 12(6), 664-675.
Mayhew J, Zhao L, Hou Y, Berwick J, Askew S, Zheng Y & Coffey P (1998) Spectroscopic investigation of reflectance changes in the barrel cortex following whisker stimulation.. Adv Exp Med Biol, 454, 139-148.
Mayhew J, Hu D, Zheng Y, Askew S, Hou Y, Berwick J, Coffey PJ & Brown N (1998) An evaluation of linear model analysis techniques for processing images of microcirculation activity.. Neuroimage, 7(1), 49-71.
Zhao M, McGarry LM, Ma H, Harris S, Berwick J, Yuste R & Schwartz TH () Optical triggered seizures using a caged 4-Aminopyridine. Frontiers in Neuroscience, 9. View this article in WRRO

Conference proceedings papers

Martin C, Berwick J, Kennerley A, Zheng Y & Mayhew J (2009) Spatiotemporal complexity in the haemodynamic response to somatosensory stimulation in the un-anaesthetized rat. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol. 29 (pp S105-S105)
Martin C, Kennerley A, Berwick J, Sibson N & Mayhew J (2009) Functional magnetic resonance imaging in un-anaesthetized rats using a chronically implanted surface coil. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol. 29 (pp S606-S607)
Zheng Y, Pan Y, Harris S, Billings S, Coca D, Berwick J, Kennerley A, Johnston D & Mayhew J (2009) A mathematical model of the neurovascular coupling suggesting both vasodilation and vasoconstriction. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol. 29 (pp S19-S20)

All publications

Journal articles

Huber LR, Poser BA, Kaas AL, Fear EJ, Dresbach S, Berwick J, Goebel R, Turner R & Kennerley AJ (2021) Validating layer-specific VASO across species.. Neuroimage, 237.
Shabir O, Moll TA, Matuszyk MM, Eyre B, Dake MD, Berwick J & Francis SE (2020) Preclinical models of disease and multimorbidity with focus upon cardiovascular disease and dementia. Mechanisms of Ageing and Development, 192, 111361-111361.
Shabir O, Sharp P, Rebollar MA, Boorman L, Howarth C, Wharton SB, Francis SE & Berwick J (2020) Enhanced cerebral blood volume under normobaric hyperoxia in the J20-hAPP mouse model of Alzheimer’s disease. Scientific Reports, 10(1). View this article in WRRO
Brezzo G, Simpson J, Ameen-Ali KE, Berwick J & Martin C (2020) Acute effects of systemic inflammation upon the neuro-glial-vascular unit and cerebrovascular function.. Brain, Behavior, & Immunity - Health, 5. View this article in WRRO
Lee L, Boorman L, Glendenning E, Christmas C, Sharp P, Redgrave P, Shabir O, Bracci E, Berwick J & Howarth C (2020) Key Aspects of Neurovascular Control Mediated by Specific Populations of Inhibitory Cortical Interneurons. Cerebral Cortex, 30(4), 2452-2464. View this article in WRRO
Sharp P, Ameen-Ali K, Boorman L, Harris S, Wharton S, Howarth C, Shabir O, Redgrave P & Berwick J (2019) Neurovascular coupling preserved in a chronic mouse model of Alzheimer’s disease: Methodology is critical.. Journal of Cerebral Blood Flow and Metabolism. View this article in WRRO
Ameen-Ali K, Simpson J, Wharton S, Heath P, Sharp P, Brezzo G & Berwick J (2019) The time course of recognition memory impairment and glial pathology in the hAPP-J20 mouse model of Alzheimer’s disease. Journal of Alzheimer's disease : JAD. View this article in WRRO
Shabir O, Berwick J & Francis S (2018) Neurovascular Dysfunction in Vascular Dementia, Alzheimer’s and Atherosclerosis. BMC Neuroscience, 19. View this article in WRRO
Harris S, Boorman L, Das D, Kennerley A, Sharp P, Martin C, Redgrave P, Schwartz T & Berwick J (2018) Physiological and pathological brain activation in the anesthetized rat produces hemodynamic-dependent cortical temperature increases that can confound the BOLD fMRI signal.. Frontiers in Neuroscience, 12. View this article in WRRO
Harris SS, Boorman L, Kennerley AJ, Sharp PS, Redgrave P, Martin C, Schwartz TH & Berwick J (2018) Seizure epicenter depth and translaminar field potential synchrony underlie complex variations in tissue oxygenation during ictal initiation. NeuroImage, 171, 165-175. View this article in WRRO
Horsburgh K, Wardlaw JM, van Agtmael T, Allan SM, Ashford MLJ, Bath PM, Brown R, Berwick J, Cader MZ, Carare RO , Davis JB et al (2018) Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology. Clinical Science, 132(8), 851-868. View this article in WRRO
Ameen-Ali KE, Wharton SB, Simpson JE, Heath PR, Sharp P & Berwick J (2017) Review: Neuropathology and behavioural features of transgenic murine models of Alzheimer's disease. Neuropathology and Applied Neurobiology, 43(7), 553-570. View this article in WRRO
Bruyns-Haylett M, Luo J, Kennerley AJ, Harris S, Boorman L, Milne E, Vautrelle N, Hayashi Y, Whalley BJ, Jones M , Berwick J et al (2017) The neurogenesis of P1 and N1: A concurrent EEG/LFP study. NeuroImage, 146, 575-588. View this article in WRRO
Bray N, Burrows FE, Jones M, Berwick J, Allan SM & Schiessl I (2016) Decreased haemodynamic response and decoupling of cortical gamma-band activity and tissue oxygen perfusion after striatal interleukin-1 injection. Journal of Neuroinflammation, 13(1), 195-195. View this article in WRRO
Slack R, Boorman L, Patel P, Harris S, Bruyns-Haylett M, Kennerley A, Jones M & Berwick J (2016) A novel method for classifying cortical state to identify the accompanying changes in cerebral haemodynamics. Journal of Neuroscience Methods, 267, 21-34. View this article in WRRO
Sharp PS, Shaw K, Boorman L, Harris S, Kennerley A, Azzouz M & Berwick J (2015) Comparison of stimulus-evoked cerebral hemodynamics in the awake mouse and under a novel anesthetic regime. Scientific Reports, 5. View this article in WRRO
Tian X, Nyberg S, S. Sharp P, Madsen J, Daneshpour N, Armes SP, Berwick J, Azzouz M, Shaw P, Abbott NJ & Battaglia G (2015) LRP-1-mediated intracellular antibody delivery to the Central Nervous System. Scientific Reports, 5, 11990-11990. View this article in WRRO
Boorman L, Harris S, Bruyns-Haylett M, Kennerley A, Zheng Y, Martin CJ, Jones M, Redgrave P & Berwick J (2015) Long-Latency Reductions in Gamma Power Predict Hemodynamic Changes That Underlie the Negative BOLD Signal. Journal of Neuroscience, 35(11), 4641-4656. View this article in WRRO
Sharp PS, Shaw K, Boorman L, Harris S, Kennerley AJ, Azzouz M & Berwick J (2015) Erratum: Corrigendum: Comparison of stimulus-evoked cerebral hemodynamics in the awake mouse and under a novel anesthetic regime. Scientific Reports, 5(1).
Harris S, Boorman L, Bruyns-Haylett M, Kennerley A, Ma H, Zhao M, Overton PG, Schwartz TH & Berwick J (2014) Contralateral dissociation between neural activity and cerebral blood volume during recurrent acute focal neocortical seizures. Epilepsia, 55(9), 1423-1430. View this article in WRRO
Harris S, Ma H, Zhao M, Boorman L, Zheng Y, Kennerley A, Bruyns-Haylett M, Overton PG, Berwick J & Schwartz TH (2014) Coupling between gamma-band power and cerebral blood volume during recurrent acute neocortical seizures.. Neuroimage, 97, 62-70. View this article in WRRO
Grant RA, Sharp PS, Kennerley AJ, Berwick J, Grierson A, Ramesh T & Prescott TJ (2014) Abnormalities in whisking behaviour are associated with lesions in brain stem nuclei in a mouse model of amyotrophic lateral sclerosis.. Behav Brain Res, 259, 274-283. View this article in WRRO
Ma H, Harris S, Rahmani R, Lacefield CO, Zhao M, Daniel AGS, Zhou Z, Bruno RM, Berwick J & Schwartz TH (2014) Wide-fieldin vivoneocortical calcium dye imaging using a convection-enhanced loading technique combined with simultaneous multiwavelength imaging of voltage-sensitive dyes and hemodynamic signals. Neurophotonics, 1(1), 015003-015003. View this article in WRRO
Harris S, Bruyns-Haylett M, Kennerley A, Boorman L, Overton PG, Ma H, Zhao M, Schwartz TH & Berwick J (2013) The effects of focal epileptic activity on regional sensory-evoked neurovascular coupling and postictal modulation of bilateral sensory processing.. J Cereb Blood Flow Metab, 33(10), 1595-1604. View this article in WRRO
Bruyns-Haylett M, Harris S, Boorman L, Zheng Y, Berwick J & Jones M (2013) The resting-state neurovascular coupling relationship: rapid changes in spontaneous neural activity in the somatosensory cortex are associated with haemodynamic fluctuations that resemble stimulus-evoked haemodynamics.. Eur J Neurosci, 38(6), 2902-2916.
Martin CJ, Kennerley AJ, Berwick J, Port M & Mayhew JEW (2013) Functional MRI in conscious rats using a chronically implanted surface coil.. J Magn Reson Imaging, 38(3), 739-744.
Kazan SM, Reynolds S, Kennerley A, Wholey E, Bluff JE, Berwick J, Cunningham VJ, Paley MN & Tozer GM (2013) Kinetic modeling of hyperpolarized (13)C pyruvate metabolism in tumors using a measured arterial input function.. Magn Reson Med, 70(4), 943-953.
Martin C, Zheng Y, Sibson NR, Mayhew JEW & Berwick J (2013) Complex spatiotemporal haemodynamic response following sensory stimulation in the awake rat.. Neuroimage, 66, 1-8.
Saka M, Berwick J & Jones M (2012) Inter-trial variability in sensory-evoked cortical hemodynamic responses: the role of the magnitude of pre-stimulus fluctuations. Frontiers in Neuroenergetics, 4. View this article in WRRO
Zheng Y, Luo JJ, Harris S, Kennerley A, Berwick J, Billings SA & Mayhew J (2012) Balanced excitation and inhibition: model based analysis of local field potentials.. Neuroimage, 63(1), 81-94.
Kennerley AJ, Mayhew JE, Boorman L, Zheng Y & Berwick J (2012) Is optical imaging spectroscopy a viable measurement technique for the investigation of the negative BOLD phenomenon? A concurrent optical imaging spectroscopy and fMRI study at high field (7 T).. Neuroimage, 61(1), 10-20.
Kennerley AJ, Harris S, Bruyns-Haylett M, Boorman L, Zheng Y, Jones M & Berwick J (2012) Early and late stimulus-evoked cortical hemodynamic responses provide insight into the neurogenic nature of neurovascular coupling. Journal of Cerebral Blood Flow and Metabolism, 32(3), 468-480.
Kennerley AJ, Harris S, Bruyns-Haylett M, Boorman L, Zheng Y, Jones M & Berwick J (2012) Early and late stimulus-evoked cortical hemodynamic responses provide insight into the neurogenic nature of neurovascular coupling.. J Cereb Blood Flow Metab, 32(3), 468-480.
Devonshire IM, Papadakis NG, Port M, Berwick J, Kennerley AJ, Mayhew JEW & Overton PG (2012) Neurovascular coupling is brain region-dependent.. Neuroimage, 59(3), 1997-2006.
Mead RJ, Bennett EJ, Kennerley AJ, Sharp P, Sunyach C, Kasher P, Berwick J, Pettmann B, Battaglia G, Azzouz M , Grierson A et al (2011) Optimised and rapid pre-clinical screening in the SOD1(G93A) transgenic mouse model of amyotrophic lateral sclerosis (ALS).. PLoS One, 6(8), e23244. View this article in WRRO
Bruyns-Haylett M, Zheng Y, Berwick J & Jones M (2010) Temporal coupling between stimulus-evoked neural activity and hemodynamic responses from individual cortical columns.. Phys Med Biol, 55(8), 2203-2219.
Boorman L, Kennerley AJ, Johnston D, Jones M, Zheng Y, Redgrave P & Berwick J (2010) Negative blood oxygen level dependence in the rat: a model for investigating the role of suppression in neurovascular coupling.. J Neurosci, 30(12), 4285-4294.
Zheng Y, Pan Y, Harris S, Billings S, Coca D, Berwick J, Jones M, Kennerley A, Johnston D, Martin C , Devonshire IM et al (2010) A dynamic model of neurovascular coupling: implications for blood vessel dilation and constriction.. Neuroimage, 52(3), 1135-1147. View this article in WRRO
Harris S, Jones M, Zheng Y & Berwick J (2010) Does neural input or processing play a greater role in the magnitude of neuroimaging signals?. Front Neuroenergetics, 2. View this article in WRRO
Saka M, Berwick J & Jones M (2010) Linear superposition of sensory-evoked and ongoing cortical hemodynamics.. Front Neuroenergetics, 2. View this article in WRRO
Kennerley AJ, Mayhew JE, Redgrave P & Berwick J (2010) Vascular Origins of BOLD and CBV fMRI Signals: Statistical Mapping and Histological Sections Compared.. Open Neuroimag J, 4, 1-8. View this article in WRRO
Kennerley AJ, Berwick J, Martindale J, Johnston D, Zheng Y & Mayhew JE (2009) Refinement of optical imaging spectroscopy algorithms using concurrent BOLD and CBV fMRI.. Neuroimage, 47(4), 1608-1619.
Jones M, Devonshire IM, Berwick J, Martin C, Redgrave P & Mayhew J (2008) Altered neurovascular coupling during information-processing states.. Eur J Neurosci, 27(10), 2758-2772.
Berwick J, Johnston D, Jones M, Martindale J, Martin C, Kennerley AJ, Redgrave P & Mayhew JEW (2008) Fine detail of neurovascular coupling revealed by spatiotemporal analysis of the hemodynamic response to single whisker stimulation in rat barrel cortex.. J Neurophysiol, 99(2), 787-798.
Gias C, Jones M, Keegan D, Adamson P, Greenwood J, Lund R, Martindale J, Johnston D, Berwick J, Mayhew J & Coffey P (2007) Preservation of visual cortical function following retinal pigment epithelium transplantation in the RCS rat using optical imaging techniques. EUR J NEUROSCI, 25(7), 1940-1948.
Martin C, Martindale J, Berwick J & Mayhew J (2006) Investigating neural-hemodynamic coupling and the hemodynamic response function in the awake rat.. Neuroimage, 32(1), 33-48.
Berwick J, Johnston D, Jones M, Martindale J, Redgrave P, McLoughlin N, Schiessl I & Mayhew JEW (2005) Neurovascular coupling investigated with two-dimensional optical imaging spectroscopy in rat whisker barrel cortex.. Eur J Neurosci, 22(7), 1655-1666.
Jones M, Berwick J, Hewson-Stoate N, Gias C & Mayhew J (2005) The effect of hypercapnia on the neural and hemodynamic responses to somatosensory stimulation.. Neuroimage, 27(3), 609-623. View this article in WRRO
Kennerley AJ, Berwick J, Martindale J, Johnston D, Papadakis N & Mayhew JE (2005) Concurrent fMRI and optical measures for the investigation of the hemodynamic response function.. Magn Reson Med, 54(2), 354-365.
Martindale J, Berwick J, Martin C, Kong Y, Zheng Y & Mayhew J (2005) Long duration stimuli and nonlinearities in the neural-haemodynamic coupling.. J Cereb Blood Flow Metab, 25(5), 651-661.
Papadakis NG, Smponias T, Berwick J & Mayhew JEW (2005) k-space correction of eddy-current-induced distortions in diffusion-weighted echo-planar imaging.. Magn Reson Med, 53(5), 1103-1111.
Hewson-Stoate N, Jones M, Martindale J, Berwick J & Mayhew J (2005) Further nonlinearities in neurovascular coupling in rodent barrel cortex.. Neuroimage, 24(2), 565-574.
Zheng Y, Johnston D, Berwick J, Chen D, Billings S & Mayhew J (2005) A three-compartment model of the hemodynamic response and oxygen delivery to brain.. Neuroimage, 28(4), 925-939.
Berwick J, Devonshire IM, Martindale AJ, Johnston D, Zheng Y, Kennerley AJ, Overton PG & Mayhew JEW (2005) Cocaine administration produces a protracted decoupling of neural and haemodynamic responses to intense sensory stimuli.. Neuroscience, 132(2), 361-374.
Berwick J, Redgrave P, Jones M, Hewson-Stoate N, Martindale J, Johnston D & Mayhew JEW (2004) Integration of neural responses originating from different regions of the cortical somatosensory map.. Brain Res, 1030(2), 284-293.
Devonshire IM, Berwick J, Jones M, Martindale J, Johnston D, Overton PG & Mayhew JEW (2004) Haemodynamic responses to sensory stimulation are enhanced following acute cocaine administration.. Neuroimage, 22(4), 1744-1753.
Martindale J, Mayhew J, Berwick J, Jones M, Martin C, Johnston D, Redgrave P & Zheng Y (2003) The hemodynamic impulse response to a single neural event.. J Cereb Blood Flow Metab, 23(5), 546-555.
Martin C, Berwick J, Johnston D, Zheng Y, Martindale J, Port M, Redgrave P & Mayhew J (2002) Optical imaging spectroscopy in the unanaesthetised rat.. J Neurosci Methods, 120(1), 25-34.
Zheng Y, Martindale J, Johnston D, Jones M, Berwick J & Mayhew J (2002) A model of the hemodynamic response and oxygen delivery to brain.. Neuroimage, 16(3 Pt 1), 617-637.
Berwick J, Martin C, Martindale J, Jones M, Johnston D, Zheng Y, Redgrave P & Mayhew J (2002) Hemodynamic response in the unanesthetized rat: intrinsic optical imaging and spectroscopy of the barrel cortex.. J Cereb Blood Flow Metab, 22(6), 670-679.
Jones M, Berwick J & Mayhew J (2002) Changes in blood flow, oxygenation, and volume following extended stimulation of rodent barrel cortex.. Neuroimage, 15(3), 474-487.
Mayhew J, Johnston D, Martindale J, Jones M, Berwick J & Zheng Y (2001) Increased oxygen consumption following activation of brain: theoretical footnotes using spectroscopic data from barrel cortex.. Neuroimage, 13(6 Pt 1), 975-987.
Jones M, Berwick J, Johnston D & Mayhew J (2001) Concurrent optical imaging spectroscopy and laser-Doppler flowmetry: the relationship between blood flow, oxygenation, and volume in rodent barrel cortex.. Neuroimage, 13(6 Pt 1), 1002-1015.
Gias C, Coffey P, Martindale J, Berwick J, Johnston D & Mayhew JEW (2001) Visual cortical function in non-dystrophic and dystrophic RCS rats as revealed by intrinsic optical imaging.. INVEST OPHTH VIS SCI, 42(4), S787-S787.
Mayhew J, Johnston D, Berwick J, Jones M, Coffey P & Zheng Y (2001) Spectroscopic analysis of neural activity in brain: Increased oxygen consumption following activation of barrel cortex (vol 12, pg 664, 2000). NEUROIMAGE, 13(3), 540-543.
Zheng Y, Johnston D, Berwick J & Mayhew J (2001) Signal source separation in the analysis of neural activity in brain.. Neuroimage, 13(3), 447-458.
Herlihy DJ, Larkman DJ, deSouza NM, Williams AD & Young IR (2001) Catheter tracking for MR fluoroscopy: Design of a transmit/receive coil for use with a nasogastric tube. Journal of Magnetic Resonance Imaging, 13(1), 127-130.
Paley M, Mayhew JE, Martindale AJ, McGinley J, Berwick J, Coffey P, Redgrave P, Furness P, Port M, Ham A , Zheng Y et al (2001) Design and initial evaluation of a low-cost 3-Tesla research system for combined optical and functional MR imaging with interventional capability.. J Magn Reson Imaging, 13(1), 87-92.
Mayhew J, Johnston D, Berwick J, Jones M, Coffey P & Zheng Y (2000) Spectroscopic analysis of neural activity in brain: increased oxygen consumption following activation of barrel cortex.. Neuroimage, 12(6), 664-675.
Martindale J, Berwick J, Johnston D, Jones M, Zheng Y, Coffey P, Paley M & Mayhew J (2000) Pseudo-random procedures for rapid presentation rates using optical imaging and spectroscopy.. Neuroreport, 11(10), 2247-2252.
Berwick J, Johnston D, Coffey PJ & Mayhew JEW (2000) Spectroscopic analysis of the action of 7-NI on the coupling of neural activity and the haemodynamic response in barrel cortex.. EUR J NEUROSCI, 12, 425-425.
Mayhew J, Zheng Y, Hou Y, Vuksanovic B, Berwick J, Askew S & Coffey P (1999) Spectroscopic analysis of changes in remitted illumination: the response to increased neural activity in brain.. Neuroimage, 10(3 Pt 1), 304-326.
Mayhew JEW, Zheng Y, Hou Y, Berwick J, Stone J, Porrill J & Coffey PJ (1999) The spatio-temporal characteristics of the response to increased neural activity. NeuroImage, 9(6 PART II).
Mayhew J, Zhao L, Hou Y, Berwick J, Askew S, Zheng Y & Coffey P (1998) Spectroscopic investigation of reflectance changes in the barrel cortex following whisker stimulation.. Adv Exp Med Biol, 454, 139-148.
Mayhew J, Hu D, Zheng Y, Askew S, Hou Y, Berwick J, Coffey PJ & Brown N (1998) An evaluation of linear model analysis techniques for processing images of microcirculation activity.. Neuroimage, 7(1), 49-71.
Zhao M, McGarry LM, Ma H, Harris S, Berwick J, Yuste R & Schwartz TH () Optical triggered seizures using a caged 4-Aminopyridine. Frontiers in Neuroscience, 9. View this article in WRRO
Shabir O, Pendry B, Lee L, Eyre B, Sharp P, Rebollar MA, Howarth C, Heath PR, Wharton SB, Francis SE & Berwick J () Assessment of Neurovascular Coupling & Cortical Spreading Depression in Mixed Models of Atherosclerosis & Alzheimer’s Disease.
Ameen-Ali KE, Simpson JE, Wharton SB, Heath PR, Sharp P, Brezzo G & Berwick J () The time course of recognition memory impairment and glial pathology in the hAPP-J20 mouse model of Alzheimer's disease..
Sharp PS, Ameen-Ali K, Boorman L, Harris S, Wharton S, Howarth C, Redgrave P & Berwick J () Neurovascular coupling preserved in a chronic mouse model of Alzheimer’s disease: Methodology is critical.
Shabir O, Pendry B, Heath PR, Rebollar MA, Howarth C, Wharton SB, Berwick J & Francis SE () Neurovascular Function in a Novel Model of Experimental Atherosclerosis.
Brezzo G, Simpson J, Ameen-Ali KE, Berwick J & Martin C () Acute effects of systemic inflammation upon neurovascular unit and cerebrovascular function..
Huber LR, Poser BA, Kaas AL, Fear EJ, Desbach S, Berwick J, Goebel R, Turner R & Kennerley AJ () Validating layer-specific VASO across species.
Eyre B, Shaw K, Sharp P, Boorman L, Lee L, Shabir O, Berwick J & Howarth C () The effects of locomotion on sensory-evoked haemodynamic responses in the cortex of awake mice.
Shabir O, Pendry B, Lee L, Eyre B, Sharp P, Rebollar M, Drew D, Howarth C, Heath P, Wharton S , Francis S et al () Assessment of neurovascular coupling and cortical spreading depression in mixed mouse models of atherosclerosis and Alzheimer’s disease. eLife.

Chapters

Devonshire IM, Zheng Y & Berwick J (2015) Voltage Sensitive Dye Imaging, Intrinsic Optical Signals, Encyclopedia of Computational Neuroscience (pp. 3144-3147). Springer New York
(2015) Vagus Nerve Stimulation, Encyclopedia of Computational Neuroscience (pp. 3025-3025). Springer New York
Devonshire IM, Zheng Y & Berwick J (2014) Voltage-Sensitive Dye Imaging, Intrinsic Optical Signals, Encyclopedia of Computational Neuroscience (pp. 1-4). Springer New York
Kennerley AJ, Boorman L, Harris S & Berwick J (2014) Simultaneous Functional Magnetic Resonance and Two-Dimensional Optical Imaging Spectroscopy, Neurovascular Coupling Methods (pp. 3-20). Springer New York

Conference proceedings papers

Das D, Kennerley AJ, Harris S & Berwick J (2017) The influence of mild hypercapnia on brain intracellular pH, phosphate metabolites and cerebral blood flow: A multi-nuclear (1H/31P) MR study at 7T. Proc. Intl. Soc. Mag. Reson. Med. (2017), 22 April 2017 - 27 April 2017.
Martin C, Berwick J, Kennerley A, Zheng Y & Mayhew J (2009) Spatiotemporal complexity in the haemodynamic response to somatosensory stimulation in the un-anaesthetized rat. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol. 29 (pp S105-S105)
Martin C, Kennerley A, Berwick J, Sibson N & Mayhew J (2009) Functional magnetic resonance imaging in un-anaesthetized rats using a chronically implanted surface coil. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol. 29 (pp S606-S607)
Zheng Y, Pan Y, Harris S, Billings S, Coca D, Berwick J, Kennerley A, Johnston D & Mayhew J (2009) A mathematical model of the neurovascular coupling suggesting both vasodilation and vasoconstriction. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol. 29 (pp S19-S20)
Mayhew J, Berwick J, Kennerley A, Martindale J, Papadakis N & Zheng Y (2004) Concurrent optical imaging spectroscopy, laser Doppler flowmetry and magnetic resonance imaging in the investigation of the relative intra and extra vascular contributions to the BOLD signal. Biomedical Topical Meeting, 2004.
Jones M, Gias C, Martin C, Berwick J, Martindale J, Johnston D, Mayhew J & Coffey P (2002) Optical imaging of visual cortex in unanaesthetised rat. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol. 43 (pp U1339-U1339)
Porrill J, Stone JV, Berwick J, Mayhew J & Coffey P (2000) Analysis of optical imaging data using weak models and ICA. ADVANCES IN INDEPENDENT COMPONENT ANALYSIS (pp 217-233)
Coffey PJ, Oliver P, Berwick J, Jones M & Mayhew J (1999) Optical imaging of visual cortex in congenic and dystrophic royal college of surgeons rats. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol. 40(4) (pp S124-S124)

Research group

Postdoctural staff

Dr Osman Shabir – Investigating the links between Atherosclerosis and Dementia

Postgraduate students

Llywelyn Lee (RA/PhD student): Using an optogenetic approach to investigate interneuron regulation of cerebral blood flow
Bethany Eyre (PhD student): Cognitive and neurovascular function in an APP/PS1 mouse model of Alzheimer’s disease.

Grants

2020-2023 British Heart Foundation Project grant: Atherosclerosis, the brain and vascular dementia – the role of inflammation in neurovascular function. Professor Sheila Francis (PI), Dr Jason Berwick (CO-I), Dr Clare Howarth, Professor Stuart Allan, and Dr Emmanuel Pinteaux: £256K
2019-2022 Battelle PhD studentship: Understanding neurovascular breakdown in the APP/PS1 mouse. Berwick J and Howarth (Joint PI’s), Vazquez A (CO-I) - £137K
2016 MRC-KHIDI UK-KOREA PARTNERING AWARDS Title: Integrating multimodal imaging technologies to investigate neurovascular dysfunction in neurological disorders Sheffield University Team: Dr Jason Berwick (PI), Dr Luke Boorman, Dr Sam Harris, Dr Paul Sharp Sungkyunkwan University Team: Professor Minah Suh (PI). Dr Eunha Baeg, Dr Chaejeong Heo, Dr Sohee Lee. Total value: £20K
2016-2018. Brain Research New Zealand. Dysfunctional Neurovascular Coupling: A precursor to Alzheimer’s? David T (PI), Berwick J (CO-I). $180K NZ Dollar.
2015 FRIENZ study tour of New Zealand – ‘Living a Long and Healthy Life. ~£10K
2015-2018 Epilepsy Research UK project grant. How activation of sensory regions can promote propagation of adjacent focal neocortical seizures. Berwick J (PI), Harris S, Schwartz T, Overton PG, Kennerley A, Zheng Y. £147K
2015-2018 Medical Research Council. Investigating the thermoregulatory role of neurovascular coupling and the anti-epileptogenic and neuroprotective effects of focal cerebral cooling. Berwick J (PI), Harris S, Martin C, Redgrave P, Boorman L, Kennerley A. ~£558K Full Fec
2014-2016 Interdisciplinary Research Grant Alzheimer’s Research UK. Neurovascular dysfunction in Alzheimer’s disease: the search for early biomarkers. Berwick J (PI), Wharton S, Heath P. ~£507K full fec
2015-2019 Wellcome Trust Health Innovation Challenge Fund – Round 8. GOLD imaging in acute stroke: further technology development incorporating a perfluorocarbon oxygen carrier. Muir K (PI), Santosh C (PI), Macrae IM, Deuchar G, Berwick J (CO-I), Kennerley AJ. £1.79M full fec (£120K to Sheffield)
2013-2016 Biotechnology and biological sciences research council. Understanding neural excitation and inhibition: implications for the interpretation of extracellular field potentials and neurovascular coupling. Zheng Y (PI), Berwick J, Jones M, Billings S, Coca D, Milne E, Redgrave P. ~£850K full fec
2011-2014 Medical Research Council. The neurophysiological basis of negative BOLD signals – Berwick J (PI), Jones M, Kennerley A, Boorman L, Martin C, Redgrave P, Zheng Y. £655K full fec
2011-2014 Wellcome Trust. Understanding Epilepsy in the active brain - Berwick J (PI), Overton PG, Schwartz T, Kennerley A, Ma H, Zhao M. ~£519K full fec
2009- 2012 EPSRC. "Engineering virus-like nanoparticles for targeting the central nervous system". G Battaglia (PI), S P. Armes, M. Azzouz, O. Bandmann, J. Berwick, P.G. Ince , A.J. Kennerley, M. Jones, R. Golestanian, R. Hose, R. Mead, K. Ning, A.J. Ryan, P. Shaw, R. Smallwood, D. Walker & Y. Zheng. £ 2,060,808;
2007 – 2010 Medical Research Council New Investigator Award entitled ‘Neurovascular Coupling under the microscope’ – Principal Investigator £415K

Teaching activities

PSY1003: Neuroscience and Clinical Psychology

PSY2003: Neuroscience and Clinical Psychology II

PSY346: Psychology 3^rd year dissertation project supervision

PSY331: Psychology 3^rd year extended essay supervision

PSY6306: Fundamentals of Neuroscience

Research Project Supervision: MSc Cognitive Neuroscience and Human Neuroimaging, MSc Cognitive and Computational Neuroscience, MSc Systems Neuroscience

Professional activities

Within the University

Assistant Faculty Director of Research and Innovation

Member of the Neuroscience Institute Executive Board

Member of University Senate Research and Innovation Committee

Member of the Departmental REF committee

Member of Animal Welfare and Ethical Review Body

Member of animal Procedures Assessment Advisory Committee

Outside of the University

Member of Biotechnology and Biological Sciences Research Council panel A grant review body.

Member of the International Society of Cerebral Blood Flow and Metabolism

Member of the Society for Neuroscience

I am a reviewer for high impact neuroscience journals which include: Nature Methods, eLife,, Journal of neuroscience, NeuroImage, Journal of cerebral blood flow and metabolism, Journal of neuroscience methods, Frontiers in Neuroenergetics, Magnetic resonance in medicine, brain research bulletin, Cold Spring Harbour Protocols and Journal of biomedical optics.

I am a grant reviewer for national and international funding organisations including the Wellcome Trust, MRC, BBSRC, Physiological Society UK, Swiss National Science foundation, French National Research Agency, Astar Consortium in Singapore, Neurological foundation of New Zealand and the Canadian Natural Sciences and Engineering Research council.