Dr Kyra Campbell
Sir Henry Dale Fellow
Room: D38a Firth Court
I have long been fascinated by the question of how cells assemble into functional tissues at both the subcellular and intercellular levels. After studying Natural Sciences at the University of Cambridge and being fired up by my final year course in Developmental Biology, I stayed on to do my PhD with Prof. Helen Skaer. In close collaboration with Prof. Elisabeth Knust, I explored how cell polarity is established and maintained as cells undergo the extensive remodelling that underlies tissue morphogenesis. For my postdoctoral training, I moved to the lab of Prof. Jordi Casanova in Barcelona, and focused on developing a novel model system for studying the mechanisms underlying cell plasticity during development, and in collaboration with Eduard Batlle’s lab at the IRB, in tumourigenesis. In 2017 I activated a Sir Henry Dale Fellowship that I was awarded by the Wellcome Trust/ The Royal Society, and started my group in the University of Sheffield.
Brief career history:
These processes are called the epithelial-to-mesenchymal transition (EMT) and the reverse mesenchymal-epithelial-transition (MET), and they enable cells to reversibly switch between stationary and migratory cell states. While many signals capable of inducing cells to undergo an EMT have been identified, about MET very little is known, and the molecular mechanisms orchestrating both processes remain poorly understood. We use the model organism of the fruit fly Drosophila melanogaster to study the basic biology of these processes during normal development and also during tumour progression in exciting new Drosophila cancer models that we have recently generated.
Postgraduate PhD studentships
We advertise PhD opportunities (Funded or Self-Funded projects) on FindAPhD.com
For further information and details of other projects on offer, please see the department PhD Opportunities page:
- Campbell K, Rossi F, Adams J, Pitsidianaki I, Barriga FM, Garcia-Gerique L, Batlle E, Casanova J & Casali A (2019) Collective cell migration and metastases induced by an epithelial-to-mesenchymal transition in Drosophila intestinal tumors. Nature Communications, 10(1).
- Campbell K (2018) Contribution of epithelial-mesenchymal transitions to organogenesis and cancer metastasis. Current Opinion in Cell Biology, 55, 30-35. View this article in WRRO
- Campbell K, LeBreton G, Franch-Marro X & Casanova J (2018) Differential roles of the Drosophila EMT-inducing transcription factors Snail and Serpent in driving primary tumour growth.. PLoS Genetics, 14(2). View this article in WRRO
- Campbell K & Casanova J (2016) A common framework for EMT and collective cell migration. Development, 143(23), 4291-4300.
- Campbell K & Casanova J (2015) A role for E-cadherin in ensuring cohesive migration of a heterogeneous population of non-epithelial cells. Nature Communications, 6(1), 7998.
- Martorell Ò, Merlos-Suárez A, Campbell K, Barriga FM, Christov CP, Miguel-Aliaga I, Batlle E, Casanova J & Casali A (2014) Conserved Mechanisms of Tumorigenesis in the Drosophila Adult Midgut. PLoS ONE, 9(2), e88413.
- Campbell K, Whissell G, Franch-Marro X, Batlle E & Casanova J (2011) Specific GATA Factors Act as Conserved Inducers of an Endodermal-EMT. Developmental Cell, 21(6), 1051-1061.
- Campbell K, Casanova J & Skaer H (2010) Mesenchymal-to-epithelial transition of intercalating cells in Drosophila renal tubules depends on polarity cues from epithelial neighbours. Mechanisms of Development, 127(7-8), 345-357.