Professor Matthew Holley: Publications
Pathophysiological changes in inner hair cell ribbon synapses in the ageing mammalian cochlea. The Journal of Physiology.
Age‐related changes in the biophysical and morphological characteristics of mouse cochlear outer hair cells. The Journal of Physiology. View this article in WRRO
Gata3 is required for the functional maturation of inner hair cells and their innervation in the mouse cochlea. The Journal of Physiology. View this article in WRRO
Coordinated calcium signalling in cochlear sensory and non‐sensory cells refines afferent innervation of outer hair cells. The EMBO Journal, 38(9), e99839-e99839.
‘Surface Transplantation’ for Nerve Injury and Repair: The Quest for Minimally Invasive Cell Delivery. Trends in Neurosciences, 41(7), 429-441. View this article in WRRO
Cells transplanted onto the surface of the glial scar reveal hidden potential for functional neural regeneration. Proceedings of the National Academy of Sciences, 112(26), E3431-E3440. View this article in WRRO
Mouse DRG Cell Line with Properties of Nociceptors. PLOS ONE, 10(6). View this article in WRRO
Cholinergic efferent synaptic transmission regulates the maturation of auditory hair cell ribbon synapses.. Open Biol, 3(11). View this article in WRRO
Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2.. Proc Natl Acad Sci U S A, 110(34), 13898-13903.
Burst activity and ultrafast activation kinetics of CaV1.3 Ca²⁺ channels support presynaptic activity in adult gerbil hair cell ribbon synapses.. J Physiol, 591(16), 3811-3820. View this article in WRRO
Presynaptic maturation in auditory hair cells requires a critical period of sensory-independent spiking activity.. Proc Natl Acad Sci U S A, 110(21), 8720-8725.
Reprogramming of Single-Cell–Derived Mesenchymal Stem Cells Into Hair Cell-Like Cells. Otology & Neurotology, 33(9), 1648-1655.
Structure and Mechanics of Supporting Cells in the Guinea Pig Organ of Corti. PLoS ONE, 7(11). View this article in WRRO
Development and function of the voltage-gated sodium current in immature mammalian cochlear inner hair cells.. PLoS One, 7(9), e45732. View this article in WRRO
The resting transducer current drives spontaneous activity in prehearing mammalian cochlear inner hair cells.. J Neurosci, 32(31), 10479-10483.
Editorial. Formal Aspects of Computing, 24(1), 1-1.
Eps8 regulates hair bundle length and functional maturation of mammalian auditory hair cells.. PLoS Biol, 9(4), e1001048. View this article in WRRO
Mechanical stress-induced reactive gliosis in the auditory nerve and cochlear nucleus Laboratory investigation. J NEUROSURG, 114(2), 414-425.
miR-96 regulates the progression of differentiation in mammalian cochlear inner and outer hair cells.. Proc Natl Acad Sci U S A, 108(6), 2355-2360.
Emx2 and early hair cell development in the mouse inner ear.. Dev Biol, 340(2), 547-556.
RNA Microarray Analysis in Prenatal Mouse Cochlea Reveals Novel IGF-I Target Genes: Implication of MEF2 and FOXM1 Transcription Factors. PLOS ONE, 5(1). View this article in WRRO
Role of phosphatase and tensin homolog in the development of the mammalian auditory system. NeuroReport, 21(10), 731-735.
Phosphatase and tensin homolog deleted on chromosome 10 regulates sensory cell proliferation and differentiation of hair bundles in the mammalian cochlea. Neuroscience.
Genomic analysis of the function of the transcription factor gata3 during development of the mammalian inner ear.. PLoS One, 4(9), e7144. View this article in WRRO
Information for gene networks in inner ear development: a study centered on the transcription factor gata2.. Hear Res, 227(1-2), 32-40.
Transplantation of conditionally immortal auditory neuroblasts to the auditory nerve. EUR J NEUROSCI, 25(8), 2307-2318.
Rebuilding lost hearing using cell transplantation. NEUROSURGERY, 60(3), 417-433.
A model for mammalian cochlear hair cell differentiation in vitro: effects of retinoic acid on cytoskeletal proteins and potassium conductances.. Eur J Neurosci, 25(4), 957-973.
Stem Cell Therapy for Hearing Loss. Otology & Neurotology, 27(3), 414-421.
Keynote review: The auditory system, hearing loss and potential targets for drug development.. Drug Discov Today, 10(19), 1269-1282.
Differentiation of an auditory neuronal cell line suitable for cell transplantation.. Eur J Neurosci, 22(2), 343-353.
Development of outward potassium currents in inner and outer hair cells from the embryonic mouse cochlea. AUDIOL NEURO-OTOL, 10(1), 22-34.
Ventral otic cell lines as developmental models of auditory epithelial and neural precursors.. Dev Dyn, 231(4), 801-814.
GATA3 and NeuroD distinguish auditory and vestibular neurons during development of the mammalian inner ear.. Mech Dev, 121(3), 287-299.
Brn-3c (POU4F3) regulates BDNF and NT-3 promoter activity. Biochemical and Biophysical Research Communications, 324(1), 372-381.
Hair cell re-growth.. Int J Pediatr Otorhinolaryngol, 67 Suppl 1, S1-S5.
Hair cell regrowth. International Congress Series, 1254, 1-6.
Errata. The Journal of Physiology, 550(3), 996-996.
Developmental changes in the expression of potassium currents of embryonic, neonatal and mature mouse inner hair cells.. J Physiol, 548(Pt 2), 383-400.
Hair necessities: Hair cell differentiation and regeneration. The Biochemist, 24(6), 9-11.
Cell lines in inner ear research.. J Neurobiol, 53(2), 306-318.
E-cadherin and the differentiation of mammalian vestibular hair cells.. Exp Cell Res, 278(1), 19-30.
Transcript profiling of functionally related groups of genes during conditional differentiation of a mammalian cochlear hair cell line.. Genome Res, 12(7), 1091-1099.
Differential expression of alpha 3 and alpha 6 integrins in the developing mouse inner ear. J COMP NEUROL, 445(2), 122-132.
Asymmetric segregation of mitochondria and mortalin correlates with the multi-lineage potential of inner ear sensory cell progenitors in vitro.. Brain Res Dev Brain Res, 133(1), 49-56.
Expression of the transcription factors GATA3 and Pax2 during development of the mammalian inner ear.. J Comp Neurol, 442(4), 378-391.
Application of new biological approaches to stimulate sensory repair and protection.. Br Med Bull, 63, 157-169.
A difficult organ to work with. LANCET, S15-S15.
Congenital deafness. A difficult organ to work with.. Lancet, 358 Suppl, S15.
Ion-age molecular motors. NATURE NEUROSCIENCE, 4(8), 771-773.
Notch Signaling and the Emergence of Auditory Hair Cells. Archives of Otolaryngology–Head & Neck Surgery, 126(10), 1244-1244.
Calcium signalling mediated by the 9 acetylcholine receptor in a cochlear cell line from the immortomouse.. J Physiol, 527 Pt 1, 49-54.
Calcium signalling mediated by the α9 acetylcholine receptor in a cochlear cell line from the Immortomouse. The Journal of Physiology, 527(1), 49-54.
Tuning in with motor proteins. Nature, 405(6783), 131-133.
Identification of differentiating cochlear hair cells in vitro. American Journal of Otolaryngology, 21(1), 130-134.
GATA3 and Pax2 expression in the mammalian inner ear during early development.. EUROPEAN JOURNAL OF NEUROSCIENCE, 12, 132-132.
Expression of membrane currents during conditional differentiation of cell lines from the mouse embryonic cochlea. EUROPEAN JOURNAL OF NEUROSCIENCE, 12, 493-493.
Differentiation of Mammalian Vestibular Hair Cells from Conditionally Immortal, Postnatal Supporting Cells. The Journal of Neuroscience, 19(21), 9445-9458. View this article in WRRO
Ionic currents expressed in a cell line derived from the organ of Corti of the Immortomouse. Pfl�gers Archiv European Journal of Physiology, 438(1), 8-14.
Auditory hair cell precursors immortalized from the mammalian inner ear. Proceedings of the Royal Society of London. Series B: Biological Sciences, 265(1406), 1595-1603.
. Journal of Neurocytology, 27(9), 637-647.
Cholinergic and voltage-activated currents expressed in a cochlear cell line derived from the Immortomouse (TM). JOURNAL OF PHYSIOLOGY-LONDON, 509P, 189P-190P.
Timed markers for the differentiation of the cuticular plate and stereocilia in hair cells from the mouse inner ear. The Journal of Comparative Neurology, 395(1), 18-28.
GATA-3 is down regulated during hair cell differentiation in the mouse cochlea. British Journal of Audiology, 32(2), 74-75.
Conditional immortalization of supporting cells from mammalian vestibular sensory epithelia.. JOURNAL OF PHYSIOLOGY-LONDON, 504P, P128-P129.
Conditional expression of the alpha 9 acetylcholine receptor subunit in immortalized cell lines from the mouse cochlea.. JOURNAL OF PHYSIOLOGY-LONDON, 504P, P126-P126.
Mechanics of microtubule bundles in pillar cells from the inner ear. Biophysical Journal, 73(4), 2241-2247.
Conditional immortalization of hair cells from the inner ear. International Journal of Developmental Neuroscience, 15(4-5), 541-552.
Production of Conditionally Immortalised Cell Lines from a Transgenic Mouse. Audiology and Neurotology, 2(1-2), 25-35.
Untitled. AUDIOLOGY AND NEURO-OTOLOGY, 2(1-2), 1-2.
Editorial. Audiology and Neurotology, 2(1-2), 1-2.
Immunologically Defined Component of the Circumferential Ring Around the Cuticular Plate in Mammalian Hair Cells. Audiology and Neurotology, 1(1), 31-40.
Mechanical properties of the lateral cortex of mammalian auditory outer hair cells. Biophysical Journal, 71(1), 421-429.
Monoclonal antibody markers for early development of the stereociliary bundles of mammalian hair cells. Journal of Neurocytology, 24(11), 853-864.
Hair and supporting-cell differentiation during the development of the avian inner ear. The Journal of Comparative Neurology, 351(1), 81-93.
Identification of a 53-kDa antigen in the fibrous sheath of avian spermatozoa. Journal of Reproductive Immunology, 29(2), 149-160.
Monoclonal antibodies specific for endoplasmic membranes of mammalian cochlear outer hair cells. Journal of Neurocytology, 23(2), 87-96.
Visualisation of domains in the avian tectorial and otolithic membranes with monoclonal antibodies. Hearing Research, 80(1), 93-104.
A membrane-based force generation mechanism in auditory sensory cells.. Proceedings of the National Academy of Sciences, 89(18), 8671-8675.
A simple in vitro method for raising monoclonal antibodies to cochlear proteins. Tissue and Cell, 24(5), 613-624.
Structure of the cortical cytoskeleton in mammalian outer hair cells. Journal of Cell Science, 102(3), 569-580.
High frequency force generation in outer hair cells from the mammalian ear. BioEssays, 13(3), 115-120.
Problems of being a cell in a soft body. Hydrobiologia, 216-217(1), 35-38.
Spectrin, actin and the structure of the cortical lattice in mammalian cochlear outer hair cells. Journal of Cell Science, 96(2), 283-291.
A cytoskeletal spring for the control of cell shape in outer hair cells isolated from the guinea pig cochlea. European Archives of Oto-Rhino-Laryngology, 247(1).
Purification of mammalian cochlear hair cells using small volume Percoll density gradients. Journal of Neuroscience Methods, 27(3), 219-224.
On the mechanism of a high-frequency force generator in outer hair cells isolated from the guinea pig cochlea. Proceedings of the Royal Society of London. Series B. Biological Sciences, 232(1269), 413-429.
TEMPERATURE-DEPENDENCE OF A FAST MOTILE RESPONSE IN ISOLATED OUTER HAIR CELLS OF THE GUINEA-PIG COCHLEA. Quarterly Journal of Experimental Physiology, 73(1), 143-145.
A cytoskeletal spring in cochlear outer hair cells. Nature, 335(6191), 635-637.
Alignment of cilia in immotile-cilia syndrome. Tissue and Cell, 18(4), 521-529.
Cell shape, spatial patterns of cilia, and mucus-net construction in the ascidian endostyle. Tissue and Cell, 18(5), 667-684.
Changes in the distribution of filament-containing septate junctions as coelenterate myoepithelial cells change shape. Tissue and Cell, 17(1), 1-11.
Adaptation of a ciliary basal apparatus to cell shape changes in a contractile epithelium. Tissue and Cell, 17(3), 321-334.
The ciliary basal apparatus is adapted to the structure and mechanics of the epithelium. Tissue and Cell, 16(2), 287-310.
The control of anthozoan cilia by the basal apparatus. Tissue and Cell, 14(4), 607-620.
The histone demethylase LSD1 regulates inner ear progenitor differentiation through interactions with Pax2 and the NuRD repressor complex. PLOS ONE, 13(1), e0191689-e0191689. View this article in WRRO
Fine Tuning of CaV1.3 Ca2+ Channel Properties in Adult Inner Hair Cells Positioned in the Most Sensitive Region of the Gerbil Cochlea. PLoS ONE, 9(11), e113750-e113750. View this article in WRRO
Functional Development of Hair Cells in the Mammalian Inner Ear, Development of Auditory and Vestibular Systems: Fourth Edition (pp. 155-188).
Functional Development of Hair Cells in the Mammalian Inner Ear, Development of Auditory and Vestibular Systems (pp. 155-188). Elsevier
Contributors, Development of Auditory and Vestibular Systems (pp. xi-xiii). Elsevier
List of Participants, Auditory Physiology and Perception (pp. xiii-xvi). Elsevier
Gene Arrays, Cell Lines, Stem Cells, and Sensory Regeneration in Mammalian Ears, Hair Cell Regeneration, Repair, and Protection (pp. 257-307). Springer New York
Conference proceedings papers
Ranking of gene regulators through differential equations and Gaussian processes. Proceedings of the 2010 IEEE International Workshop on Machine Learning for Signal Processing, MLSP 2010 (pp 154-159)
An ear in a test tube. British Journal of Audiology, Vol. 34(2) (pp 77-124)
GATA3 is expressed in progenitors of supporting cells, hair cells and spiral ganglion cells during cochlear development in the mouse. BRITISH JOURNAL OF AUDIOLOGY, Vol. 34(2) (pp 78-79)
Characterization of clonal cell lines from the mouse cochlea. British Journal of Audiology, Vol. 31(2) (pp 85)
Conditionally immortalised cell lines from mouse vestibular epithelia. British Journal of Audiology, Vol. 30(2) (pp 91-92)
A cochlear specific antigen in the guinea pig and the mouse. British Journal of Audiology, Vol. 30(2) (pp 91)
Production of conditionally immortalised cells from the mouse cochlea. British Journal of Audiology, Vol. 30(2) (pp 92)
Mechanical properties of the lateral cortex of outer hair cells from the guinea pig. British Journal of Audiology, Vol. 30(2) (pp 141)