Professor Matthew Holley: Publications
Bardhan T, Jeng JY, Waldmann M, Ceriani F, Johnson SL, Olt J, Rüttiger L, Marcotti W & Holley MC (2019)
Gata3 is required for the functional maturation of inner hair cells and their innervation in the mouse cochlea. The Journal of Physiology. View this article in WRRO
Ceriani F, Hendry A, Jeng JY, Johnson SL, Stephani F, Olt J, Holley MC, Mammano F, Engel J, Kros CJ , Simmons DD et al (2019)
Coordinated calcium signalling in cochlear sensory and non‐sensory cells refines afferent innervation of outer hair cells. The EMBO Journal, 38(9), e99839-e99839.
Sekiya T & Holley MC (2018)
‘Surface Transplantation’ for Nerve Injury and Repair: The Quest for Minimally Invasive Cell Delivery. Trends in Neurosciences, 41(7), 429-441. View this article in WRRO
Sekiya T, Holley MC, Hashido K, Ono K, Shimomura K, Horie RT, Hamaguchi K, Yoshida A, Sakamoto T & Ito J (2015)
Cells transplanted onto the surface of the glial scar reveal hidden potential for functional neural regeneration. Proceedings of the National Academy of Sciences, 112(26), E3431-E3440. View this article in WRRO
Doran C, Chetrit J, Holley MC, Grundy D & Nassar MA (2015)
Mouse DRG Cell Line with Properties of Nociceptors. PLOS ONE, 10(6). View this article in WRRO
Johnson SL, Wedemeyer C, Vetter DE, Adachi R, Holley MC, Elgoyhen AB & Marcotti W (2013)
Cholinergic efferent synaptic transmission regulates the maturation of auditory hair cell ribbon synapses.. Open Biol, 3(11). View this article in WRRO
Furness DN, Johnson SL, Manor U, Rüttiger L, Tocchetti A, Offenhauser N, Olt J, Goodyear RJ, Vijayakumar S, Dai Y , Hackney CM et al (2013)
Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2.. Proc Natl Acad Sci U S A, 110(34), 13898-13903.
Zampini V, Johnson SL, Franz C, Knipper M, Holley MC, Magistretti J, Masetto S & Marcotti W (2013)
Burst activity and ultrafast activation kinetics of CaV1.3 Ca²⁺ channels support presynaptic activity in adult gerbil hair cell ribbon synapses.. J Physiol, 591(16), 3811-3820. View this article in WRRO
Johnson SL, Kuhn S, Franz C, Ingham N, Furness DN, Knipper M, Steel KP, Adelman JP, Holley MC & Marcotti W (2013)
Presynaptic maturation in auditory hair cells requires a critical period of sensory-independent spiking activity.. Proc Natl Acad Sci U S A, 110(21), 8720-8725.
Lin Z, Perez P, Sun Z, Liu J-J, Shin JH, Hyrc KL, Samways D, Egan T, Holley MC & Bao J (2012)
Reprogramming of Single-Cell–Derived Mesenchymal Stem Cells Into Hair Cell-Like Cells. Otology & Neurotology, 33(9), 1648-1655.
Zetes DE, Tolomeo JA & Holley MC (2012)
Structure and Mechanics of Supporting Cells in the Guinea Pig Organ of Corti. PLoS ONE, 7(11). View this article in WRRO
Eckrich T, Varakina K, Johnson SL, Franz C, Singer W, Kuhn S, Knipper M, Holley MC & Marcotti W (2012)
Development and function of the voltage-gated sodium current in immature mammalian cochlear inner hair cells.. PLoS One, 7(9), e45732. View this article in WRRO
Johnson SL, Kennedy HJ, Holley MC, Fettiplace R & Marcotti W (2012)
The resting transducer current drives spontaneous activity in prehearing mammalian cochlear inner hair cells.. J Neurosci, 32(31), 10479-10483.
Boiten E, Derrick J, Dong JS & Reeves S (2012)
Editorial. Formal Aspects of Computing, 24(1), 1-1.
Zampini V, Rüttiger L, Johnson SL, Franz C, Furness DN, Waldhaus J, Xiong H, Hackney CM, Holley MC, Offenhauser N , Di Fiore PP et al (2011)
Eps8 regulates hair bundle length and functional maturation of mammalian auditory hair cells.. PLoS Biol, 9(4), e1001048. View this article in WRRO
Sekiya T, Matsumoto M, Kojima K, Ono K, Kikkawa YS, Kada S, Ogita H, Horie RT, Viola A, Holley MC & Ito J (2011)
Mechanical stress-induced reactive gliosis in the auditory nerve and cochlear nucleus Laboratory investigation. J NEUROSURG, 114(2), 414-425.
Kuhn S, Johnson SL, Furness DN, Chen J, Ingham N, Hilton JM, Steffes G, Lewis MA, Zampini V, Hackney CM , Masetto S et al (2011)
miR-96 regulates the progression of differentiation in mammalian cochlear inner and outer hair cells.. Proc Natl Acad Sci U S A, 108(6), 2355-2360.
Holley M, Rhodes C, Kneebone A, Herde MK, Fleming M & Steel KP (2010)
Emx2 and early hair cell development in the mouse inner ear.. Dev Biol, 340(2), 547-556.
Sanchez-Calderon H, Rodriguez-de la Rosa L, Milo M, Pichel JG, Holley M & Varela-Nieto I (2010)
RNA Microarray Analysis in Prenatal Mouse Cochlea Reveals Novel IGF-I Target Genes: Implication of MEF2 and FOXM1 Transcription Factors. PLOS ONE, 5(1). View this article in WRRO
Dong Y, Sui L, Yamaguchi F, Kamitori K, Hirata Y, Suzuki A, Holley M & Tokuda M (2010)
Role of phosphatase and tensin homolog in the development of the mammalian auditory system. NeuroReport, 21(10), 731-735.
Dong Y, Sui L, Yamaguchi F, Kamitori K, Hirata Y, Hossain MA, Suzuki A, Holley MC & Tokuda M (2010) Phosphatase and tensin homolog deleted on chromosome 10 regulates sensory cell proliferation and differentiation of hair bundles in the mammalian cochlea.
Milo M, Cacciabue-Rivolta D, Kneebone A, Van Doorninck H, Johnson C, Lawoko-Kerali G, Niranjan M, Rivolta M & Holley M (2009)
Genomic analysis of the function of the transcription factor gata3 during development of the mammalian inner ear.. PLoS One, 4(9), e7144. View this article in WRRO
Holley MC, Kneebone A & Milo M (2007)
Information for gene networks in inner ear development: a study centered on the transcription factor gata2.. Hear Res, 227(1-2), 32-40.
Sekiya T, Holley MC, Kojima K, Matsumoto M, Helyer R & Ito J (2007)
Transplantation of conditionally immortal auditory neuroblasts to the auditory nerve. EUR J NEUROSCI, 25(8), 2307-2318.
Sekiya T, Kojima K, Matsumoto M, Holley MC & Ito J (2007)
Rebuilding lost hearing using cell transplantation. NEUROSURGERY, 60(3), 417-433.
Helyer R, Cacciabue-Rivolta D, Davies D, Rivolta MN, Kros CJ & Holley MC (2007)
A model for mammalian cochlear hair cell differentiation in vitro: effects of retinoic acid on cytoskeletal proteins and potassium conductances.. Eur J Neurosci, 25(4), 957-973.
Liu J-J, Shin JH, Hyrc KL, Liu S, Lei D, Holley MC & Bao J (2006)
Stem Cell Therapy for Hearing Loss. Otology & Neurotology, 27(3), 414-421.
Holley MC (2005)
Keynote review: The auditory system, hearing loss and potential targets for drug development.. Drug Discov Today, 10(19), 1269-1282.
Nicholl AJ, Kneebone A, Davies D, Cacciabue-Rivolta DI, Rivolta MN, Coffey P & Holley MC (2005)
Differentiation of an auditory neuronal cell line suitable for cell transplantation.. Eur J Neurosci, 22(2), 343-353.
Helyer RJ, Kennedy HJ, Davies D, Holley MC & Kros CJ (2005)
Development of outward potassium currents in inner and outer hair cells from the embryonic mouse cochlea. AUDIOL NEURO-OTOL, 10(1), 22-34.
Lawoko-Kerali G, Milo M, Davies D, Halsall A, Helyer R, Johnson CM, Rivolta MN, Tones MA & Holley MC (2004)
Ventral otic cell lines as developmental models of auditory epithelial and neural precursors.. Dev Dyn, 231(4), 801-814.
Lawoko-Kerali G, Rivolta MN, Lawlor P, Cacciabue-Rivolta DI, Langton-Hewer C, van Doorninck JH & Holley MC (2004)
GATA3 and NeuroD distinguish auditory and vestibular neurons during development of the mammalian inner ear.. Mech Dev, 121(3), 287-299.
Clough RL, Sud R, Davis-Silberman N, Hertzano R, Avraham KB, Holley M & Dawson SJ (2004)
Brn-3c (POU4F3) regulates BDNF and NT-3 promoter activity. Biochemical and Biophysical Research Communications, 324(1), 372-381.
Holley MC (2003)
Hair cell re-growth.. Int J Pediatr Otorhinolaryngol, 67 Suppl 1, S1-S5.
Holley MC (2003)
Hair cell regrowth. International Congress Series, 1254, 1-6.
Errata. The Journal of Physiology, 550(3), 996-996.
Marcotti W, Johnson SL, Holley MC & Kros CJ (2003)
Developmental changes in the expression of potassium currents of embryonic, neonatal and mature mouse inner hair cells.. J Physiol, 548(Pt 2), 383-400.
Holley M (2002)
Hair necessities: Hair cell differentiation and regeneration. The Biochemist, 24(6), 9-11.
Rivolta MN & Holley MC (2002)
Cell lines in inner ear research.. J Neurobiol, 53(2), 306-318.
Hackett L, Davies D, Helyer R, Kennedy H, Kros C, Lawlor P, Rivolta MN & Holley M (2002)
E-cadherin and the differentiation of mammalian vestibular hair cells.. Exp Cell Res, 278(1), 19-30.
Rivolta MN, Halsall A, Johnson CM, Tones MA & Holley MC (2002)
Transcript profiling of functionally related groups of genes during conditional differentiation of a mammalian cochlear hair cell line.. Genome Res, 12(7), 1091-1099.
Davies D & Holley MC (2002)
Differential expression of alpha 3 and alpha 6 integrins in the developing mouse inner ear. J COMP NEUROL, 445(2), 122-132.
Rivolta MN & Holley MC (2002)
Asymmetric segregation of mitochondria and mortalin correlates with the multi-lineage potential of inner ear sensory cell progenitors in vitro.. Brain Res Dev Brain Res, 133(1), 49-56.
Lawoko-Kerali G, Rivolta MN & Holley M (2002)
Expression of the transcription factors GATA3 and Pax2 during development of the mammalian inner ear.. J Comp Neurol, 442(4), 378-391.
Holley MC (2002)
Application of new biological approaches to stimulate sensory repair and protection.. Br Med Bull, 63, 157-169.
Holley M (2001)
Congenital deafness. A difficult organ to work with.. Lancet, 358 Suppl, S15.
Holley M (2001) A difficult organ to work with.
Meech R & Holley M (2001)
Ion-age molecular motors. NATURE NEUROSCIENCE, 4(8), 771-773.
Weir J, Rivolta MN & Holley MC (2000)
Notch Signaling and the Emergence of Auditory Hair Cells. Archives of Otolaryngology–Head & Neck Surgery, 126(10), 1244-1244.
Jagger DJ, Griesinger CB, Rivolta MN, Holley MC & Ashmore JF (2000) Calcium signalling mediated by the 9 acetylcholine receptor in a cochlear cell line from the immortomouse..
J Physiol, 527 Pt 1, 49-54.
Jagger DJ, Griesinger CB, Rivolta MN, Holley MC & Ashmore JF (2000)
Calcium signalling mediated by the α9 acetylcholine receptor in a cochlear cell line from the Immortomouse. The Journal of Physiology, 527(1), 49-54.
Holley M (2000)
Tuning in with motor proteins. Nature, 405(6783), 131-133.
WEIR J, RIVOLTA M & HOLLEY M (2000)
Identification of differentiating cochlear hair cells in vitro. American Journal of Otolaryngology, 21(1), 130-134.
Helyer RJ, Lawoko G, Rivolta MN, Holley MC & Kros CJ (2000) Expression of membrane currents during conditional differentiation of cell lines from the mouse embryonic cochlea.
EUROPEAN JOURNAL OF NEUROSCIENCE, 12, 493-493.
Lawoko GK, Rivolta MN & Holley MC (2000) GATA3 and Pax2 expression in the mammalian inner ear during early development..
EUROPEAN JOURNAL OF NEUROSCIENCE, 12, 132-132.
Lawlor P, Marcotti W, Rivolta MN, Kros CJ & Holley MC (1999)
Differentiation of Mammalian Vestibular Hair Cells from Conditionally Immortal, Postnatal Supporting Cells. The Journal of Neuroscience, 19(21), 9445-9458. View this article in WRRO
Jagger DJ, Holley MC & Ashmore JF (1999)
Ionic currents expressed in a cell line derived from the organ of Corti of the Immortomouse. Pfl�gers Archiv European Journal of Physiology, 438(1), 8-14.
Rivolta MN, Grix N, Lawlor P, Ashmore JF, Jagger DJ & Holley MC (1998)
Auditory hair cell precursors immortalized from the mammalian inner ear. Proceedings of the Royal Society of London. Series B: Biological Sciences, 265(1406), 1595-1603.
RIVOLTA MARCELON & HOLLEY MATTHEWC (1998)
. Journal of Neurocytology, 27(9), 637-647.
Jagger DJ, Rivolta MN, Holley MC & Ashmore JF (1998) Cholinergic and voltage-activated currents expressed in a cochlear cell line derived from the Immortomouse (TM).
JOURNAL OF PHYSIOLOGY-LONDON, 509P, 189P-190P.
Nishida Y, Rivolta MN & Holley MC (1998)
Timed markers for the differentiation of the cuticular plate and stereocilia in hair cells from the mouse inner ear. The Journal of Comparative Neurology, 395(1), 18-28.
Rivolta MN & Holley MC (1998) GATA-3 is down regulated during hair cell differentiation in the mouse cochlea.
British Journal of Audiology, 32(2), 74-75.
Rivolta MN, Grix N, Lawlor P & Holley MC (1997) Conditional expression of the alpha 9 acetylcholine receptor subunit in immortalized cell lines from the mouse cochlea..
JOURNAL OF PHYSIOLOGY-LONDON, 504P, P126-P126.
Lawlor P, Rivolta MN & Holley MC (1997) Conditional immortalization of supporting cells from mammalian vestibular sensory epithelia..
JOURNAL OF PHYSIOLOGY-LONDON, 504P, P128-P129.
Tolomeo JA & Holley MC (1997)
Mechanics of microtubule bundles in pillar cells from the inner ear. Biophysical Journal, 73(4), 2241-2247.
Holley MC, Nishida Y & Grix N (1997)
Conditional immortalization of hair cells from the inner ear. International Journal of Developmental Neuroscience, 15(4-5), 541-552.
Holley MC & Rivolta MN (1997)
Untitled. AUDIOLOGY AND NEURO-OTOLOGY, 2(1-2), 1-2.
Holley MC & Lawlor PW (1997)
Production of Conditionally Immortalised Cell Lines from a Transgenic Mouse. Audiology and Neurotology, 2(1-2), 25-35.
Holley MC & Rivolta MN (1997)
Editorial. Audiology and Neurotology, 2(1-2), 1-2.
Nishida Y & Holley MC (1996)
Immunologically Defined Component of the Circumferential Ring Around the Cuticular Plate in Mammalian Hair Cells. Audiology and Neurotology, 1(1), 31-40.
Tolomeo JA, Steele CR & Holley MC (1996)
Mechanical properties of the lateral cortex of mammalian auditory outer hair cells. Biophysical Journal, 71(1), 421-429.
Holley MC & Nishida Y (1995)
Monoclonal antibody markers for early development of the stereociliary bundles of mammalian hair cells. Journal of Neurocytology, 24(11), 853-864.
Goodyear R, Holley M & Richardson G (1995)
Hair and supporting-cell differentiation during the development of the avian inner ear. The Journal of Comparative Neurology, 351(1), 81-93.
Bozkurt HH & Holley MC (1995)
Identification of a 53-kDa antigen in the fibrous sheath of avian spermatozoa. Journal of Reproductive Immunology, 29(2), 149-160.
Holley MC & Richardson GP (1994)
Monoclonal antibodies specific for endoplasmic membranes of mammalian cochlear outer hair cells. Journal of Neurocytology, 23(2), 87-96.
Goodyear R, Holley M & Richardson G (1994)
Visualisation of domains in the avian tectorial and otolithic membranes with monoclonal antibodies. Hearing Research, 80(1), 93-104.
Kalinec F, Holley MC, Iwasa KH, Lim DJ & Kachar B (1992)
A membrane-based force generation mechanism in auditory sensory cells.. Proceedings of the National Academy of Sciences, 89(18), 8671-8675.
Holley MC (1992)
A simple in vitro method for raising monoclonal antibodies to cochlear proteins. Tissue and Cell, 24(5), 613-624.
Holley MC, Kalinec F & Kachar B (1992) Structure of the cortical cytoskeleton in mammalian outer hair cells.
Journal of Cell Science, 102(3), 569-580.
Holley M (1991)
High frequency force generation in outer hair cells from the mammalian ear. BioEssays, 13(3), 115-120.
Holley MC (1991)
Problems of being a cell in a soft body. Hydrobiologia, 216-217(1), 35-38.
Holley MC & Ashmore JF (1990) Spectrin, actin and the structure of the cortical lattice in mammalian cochlear outer hair cells.
Journal of Cell Science, 96(2), 283-291.
Holley MC & Ashmore JF (1990)
A cytoskeletal spring for the control of cell shape in outer hair cells isolated from the guinea pig cochlea. European Archives of Oto-Rhino-Laryngology, 247(1).
Holley MC (1989)
Purification of mammalian cochlear hair cells using small volume Percoll density gradients. Journal of Neuroscience Methods, 27(3), 219-224.
On the mechanism of a high-frequency force generator in outer hair cells isolated from the guinea pig cochlea. Proceedings of the Royal Society of London. Series B. Biological Sciences, 232(1269), 413-429.
Ashmore JF & Holley MC (1988)
TEMPERATURE-DEPENDENCE OF A FAST MOTILE RESPONSE IN ISOLATED OUTER HAIR CELLS OF THE GUINEA-PIG COCHLEA. Quarterly Journal of Experimental Physiology, 73(1), 143-145.
Holley MC & Ashmore JF (1988)
A cytoskeletal spring in cochlear outer hair cells. Nature, 335(6191), 635-637.
Holley MC & Afzelius BA (1986)
Alignment of cilia in immotile-cilia syndrome. Tissue and Cell, 18(4), 521-529.
Holley MC (1986)
Cell shape, spatial patterns of cilia, and mucus-net construction in the ascidian endostyle. Tissue and Cell, 18(5), 667-684.
Holley MC (1985)
Changes in the distribution of filament-containing septate junctions as coelenterate myoepithelial cells change shape. Tissue and Cell, 17(1), 1-11.
Holley MC (1985)
Adaptation of a ciliary basal apparatus to cell shape changes in a contractile epithelium. Tissue and Cell, 17(3), 321-334.
Holley MC (1984)
The ciliary basal apparatus is adapted to the structure and mechanics of the epithelium. Tissue and Cell, 16(2), 287-310.
Holley MC (1982)
The control of anthozoan cilia by the basal apparatus. Tissue and Cell, 14(4), 607-620.
Patel D, Shimomura A, Majumdar S, Holley MC & Hashino E ()
The histone demethylase LSD1 regulates inner ear progenitor differentiation through interactions with Pax2 and the NuRD repressor complex. PLOS ONE, 13(1), e0191689-e0191689. View this article in WRRO
Zampini V, Johnson SL, Franz C, Knipper M, Holley MC, Magistretti J, Russo G, Marcotti W & Masetto S () Fine Tuning of CaV1.3 Ca2+ Channel Properties in Adult Inner Hair Cells Positioned in the Most Sensitive Region of the Gerbil Cochlea. PLoS ONE, 9(11), e113750-e113750. View this article in WRRO
Corns LF, Bardhan T, Houston O, Olt J, Holley MC, Masetto S, Johnson SL & Marcotti W (2014)
Functional Development of Hair Cells in the Mammalian Inner Ear, Development of Auditory and Vestibular Systems: Fourth Edition (pp. 155-188).
Corns LF, Bardhan T, Houston O, Olt J, Holley MC, Masetto S, Johnson SL & Marcotti W (2014)
Functional Development of Hair Cells in the Mammalian Inner Ear, Development of Auditory and Vestibular Systems (pp. 155-188). Elsevier
Alexander EE, Altieri SC, Avraham KB, Bardhan T, Baxendale S, Beraneck M, Bhonker Y, Cardon G, Chen P, Clause A , Contreras J et al (2014)
Contributors, Development of Auditory and Vestibular Systems (pp. xi-xiii). Elsevier
ALLEN JB, ASHMORE JF, ARAN JM, AVAN P, BAKER RJ, BARUCH C, BERG BG, BERTOLOTTO C, BIALEK W, BILSEN FA , BLAUERT J et al (1992)
List of Participants, Auditory Physiology and Perception (pp. xiii-xvi). Elsevier
Rivolta MN & Holley MC () Gene Arrays, Cell Lines, Stem Cells, and Sensory Regeneration in Mammalian Ears, Hair Cell Regeneration, Repair, and Protection (pp. 257-307). Springer New York
Conference proceedings papers
Honkela A, Milo M, Holley M, Rattray M & Lawrence ND (2010)
Ranking of gene regulators through differential equations and Gaussian processes. Proceedings of the 2010 IEEE International Workshop on Machine Learning for Signal Processing, MLSP 2010 (pp 154-159)
Holley MC, Lawlor P, Lawoko G & Rivolta MN (2000)
An ear in a test tube. British Journal of Audiology, Vol. 34(2) (pp 77-124)
Lawoko G, Petrich-Marquesini LG, Cacciabue-Rivolta D, Rivolta MN & Holley MC (2000) GATA3 is expressed in progenitors of supporting cells, hair cells and spiral ganglion cells during cochlear development in the mouse.
BRITISH JOURNAL OF AUDIOLOGY, Vol. 34(2) (pp 78-79)
Grix N & Holley MC (1997) Characterization of clonal cell lines from the mouse cochlea.
British Journal of Audiology, Vol. 31(2) (pp 85)
Henderson CG & Holley MC (1996) Conditionally immortalised cell lines from mouse vestibular epithelia.
British Journal of Audiology, Vol. 30(2) (pp 91-92)
Nishida Y & Holley MC (1996) A cochlear specific antigen in the guinea pig and the mouse.
British Journal of Audiology, Vol. 30(2) (pp 91)
Grix N & Holley MC (1996) Production of conditionally immortalised cells from the mouse cochlea.
British Journal of Audiology, Vol. 30(2) (pp 92)
Tolomeo J, Holley M & Steele C (1996) Mechanical properties of the lateral cortex of outer hair cells from the guinea pig. British Journal of Audiology, Vol. 30(2) (pp 141)