Dr Daniel Humphreys
Typhoid toxin exhausts the RPA response to DNA replication stress driving senescence and Salmonella infection. Nature Communications, 10(1). View this article in WRRO
Arf GTPase interplay with Rho GTPases in regulation of the actin cytoskeleton. Small GTPases. View this article in WRRO
MYO6 is targeted by Salmonella virulence effectors to trigger PI3-kinase signaling and pathogen invasion into host cells. Proceedings of the National Academy of Sciences, 114(15), 3915-3920. View this article in WRRO
Inhibition of WAVE Regulatory Complex Activation by a Bacterial Virulence Effector Counteracts Pathogen Phagocytosis. Cell Reports, 17(3), 697-707. View this article in WRRO
The Arf GTPase-Activating Protein Family Is Exploited by Salmonella enterica Serovar Typhimurium To Invade Nonphagocytic Host Cells. mBio, 6(1).
Arf6 coordinates actin assembly through the WAVE complex, a mechanism usurped by Salmonella to invade host cells. Proceedings of the National Academy of Sciences, 110(42), 16880-16885.
Salmonella Virulence Effector SopE and Host GEF ARNO Cooperate to Recruit and Activate WAVE to Trigger Bacterial Invasion. Cell Host & Microbe, 11(2), 129-139.
The Drosophila Arf1 homologue Arf79F is essential for lamellipodium formation. Journal of Cell Science, 125(23), 5630-5635.
WAVE regulatory complex activation by cooperating GTPases Arf and Rac1. Proceedings of the National Academy of Sciences, 108(35), 14449-14454.
Enteropathogenic Escherichia coli Recruits the Cellular Inositol Phosphatase SHIP2 to Regulate Actin-Pedestal Formation. Cell Host & Microbe, 7(1), 13-24.
The Salmonella Effector SptP Dephosphorylates Host AAA+ ATPase VCP to Promote Development of its Intracellular Replicative Niche. Cell Host & Microbe, 5(3), 225-233.
Nucleotide Binding by Lhs1p Is Essential for Its Nucleotide Exchange Activity and for Functionin Vivo. Journal of Biological Chemistry, 284(46), 31564-31571.
Salmonella takes control: effector-driven manipulation of the host. Current Opinion in Microbiology, 12(1), 117-124.
Sequence divergence in type III secretion gene clusters of the Burkholderia cepacia complex. FEMS Microbiology Letters, 235(2), 229-235.
Transition to the open state of the TolC periplasmic tunnel entrance. Proceedings of the National Academy of Sciences of the United States of America, 99.