Dr Daniel Humphreys
Ibler AEM, ElGhazaly M, Naylor KL, Bulgakova NA, F. El-Khamisy S & Humphreys D (2019)
Typhoid toxin exhausts the RPA response to DNA replication stress driving senescence and Salmonella infection. Nature Communications, 10(1). View this article in WRRO
Singh V, Davidson AC, Hume PJ, Humphreys D & Koronakis V (2017)
Arf GTPase interplay with Rho GTPases in regulation of the actin cytoskeleton. Small GTPases. View this article in WRRO
Brooks ABE, Humphreys D, Singh V, Davidson AC, Arden SD, Buss F & Koronakis V (2017)
MYO6 is targeted by Salmonella virulence effectors to trigger PI3-kinase signaling and pathogen invasion into host cells. Proceedings of the National Academy of Sciences, 114(15), 3915-3920. View this article in WRRO
Humphreys D, Singh V & Koronakis V (2016)
Inhibition of WAVE Regulatory Complex Activation by a Bacterial Virulence Effector Counteracts Pathogen Phagocytosis. Cell Reports, 17(3), 697-707. View this article in WRRO
Davidson AC, Humphreys D, Brooks ABE, Hume PJ & Koronakis V (2015)
The Arf GTPase-Activating Protein Family Is Exploited by Salmonella enterica Serovar Typhimurium To Invade Nonphagocytic Host Cells. mBio, 6(1).
Humphreys D, Davidson AC, Hume PJ, Makin LE & Koronakis V (2013)
Arf6 coordinates actin assembly through the WAVE complex, a mechanism usurped by Salmonella to invade host cells. Proceedings of the National Academy of Sciences, 110(42), 16880-16885.
Humphreys D, Davidson A, Hume PJ & Koronakis V (2012)
Salmonella Virulence Effector SopE and Host GEF ARNO Cooperate to Recruit and Activate WAVE to Trigger Bacterial Invasion. Cell Host & Microbe, 11(2), 129-139.
Humphreys D, Liu T, Davidson AC, Hume PJ & Koronakis V (2012)
The Drosophila Arf1 homologue Arf79F is essential for lamellipodium formation. Journal of Cell Science, 125(23), 5630-5635.
Koronakis V, Hume PJ, Humphreys D, Liu T, Horning O, Jensen ON & McGhie EJ (2011)
WAVE regulatory complex activation by cooperating GTPases Arf and Rac1. Proceedings of the National Academy of Sciences, 108(35), 14449-14454.
Smith K, Humphreys D, Hume PJ & Koronakis V (2010)
Enteropathogenic Escherichia coli Recruits the Cellular Inositol Phosphatase SHIP2 to Regulate Actin-Pedestal Formation. Cell Host & Microbe, 7(1), 13-24.
Humphreys D, Hume PJ & Koronakis V (2009)
The Salmonella Effector SptP Dephosphorylates Host AAA+ ATPase VCP to Promote Development of its Intracellular Replicative Niche. Cell Host & Microbe, 5(3), 225-233.
de Keyzer J, Steel GJ, Hale SJ, Humphries D & Stirling CJ (2009)
Nucleotide Binding by Lhs1p Is Essential for Its Nucleotide Exchange Activity and for Functionin Vivo. Journal of Biological Chemistry, 284(46), 31564-31571.
McGhie EJ, Brawn LC, Hume PJ, Humphreys D & Koronakis V (2009)
Salmonella takes control: effector-driven manipulation of the host. Current Opinion in Microbiology, 12(1), 117-124.
GLENDINNING K (2004)
Sequence divergence in type III secretion gene clusters of the Burkholderia cepacia complex. FEMS Microbiology Letters, 235(2), 229-235.
Andersen C, Koronakis E, Bokma E, Eswaran J, Humphreys D, Hughes C & Koronakis V (2002) Transition to the open state of the TolC periplasmic tunnel entrance. Proceedings of the National Academy of Sciences of the United States of America, 99.