Image-Based Computational Haemodynamics of the Aorta: Respecting the Physics
Supervisor: Dr Alberto Marzo

Aortic coarctation is a congenital condition that consists of a local restriction in the aortic diameter. Indication for treatment is based upon measurement of blood-pressure difference across the vessel restriction. These measurements are invasive (a catheter is needed to guide the pressure sensor to the desired location), and often difficult to perform in the narrower vessels of infants. These measurements can be performed using CFD ( on patient-specific geometries extracted from medical images. The effects of vessel wall motion on haemodynamics may be significant.

This study focuses on the effect of wall motion haemodynamic of the diseased aorta. Despite the increasing spatial and temporal resolution in modern imaging modalities, we still cannot capture the motion with the resolution and confidence that we need to impose wall motion directly on an incompressible fluid domain without expecting major pressure fluctuations.

This project will develop novel techniques to extract wall motion from medical images, while respecting the physical constraints of the governing equations, and thus avoiding spurious pressure fluctuations that may adverely affect the numerical predictions. Previous knowledge of the clinical subject area is not required, although candidates should demonstrate an interest in learning those clinical aspects that are relevant to the development of the models.

This project will use the methodologies and tools developed within the Virtual Physiological Human initiative, and will be supported by the expertise available within the INSIGNEO institute.

Collaboration: Medical Physics at University of Sheffield and King's College London.
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