Dr Hannes Maib
School of Biosciences
Full contact details
School of Biosciences
• 2023 – Present - Wellcome Trust Early Career Fellow, University of Sheffield
• 2019-2023 - Postdoctoral Research Assistant, University of Dundee, Cell and Developmental Biology, Supervisor: Dr. David Murray
• 2015-2019 - PhD University of Sheffield, Supervisor: Prof Elizabeth Smythe
• 2013-2015 - MSc, Life and Medical Sciences, University of Bonn, Germany Supervisor: Prof Thorsten Lang
• 2010-2013 - Bsc, Molekulare Biomedizin, University of Bonn
- Research interests
Membrane identity changes in control of contact site formation
Membrane identity is key to cellular function, with each organelle displaying distinct identity determinants. Among the main factors imposing this are phosphoinositides, a small family of phospholipids that act as signpost of membrane identity. Lipid kinases and phosphatases are capable of interconverting these lipids by addition or removal of phosphate groups, leading to 8 distinct phosphoinositides. Key interest of my lab is to understand how these conversion cascades are regulated and how these changes to membrane identity influence cellular processes. The recent realisation that almost all organelles are in constant communication with each other, through formation of dynamic membrane contact sites, has opened up new questions regarding the interplay of membrane identity and contact site formation. Importantly, these contact sites are essential for the intracellular transport of lipids and misregulation is associated with disease and hereditary disorders. Therefore, it is essential to gain a better understanding of the molecular mechanisms that regulate this fundamental aspect of cell biology in order to develop novel interventions.
- A PI(3,5)P2 reporter reveals PIKfyve activity and dynamics on macropinosomes and phagosomes. Journal of Cell Biology, 222(9).
- A mechanism for exocyst-mediated tethering via Arf6 and PIP5K1C-driven phosphoinositide conversion. Current Biology, 32(13), 2821-2833.e6.
- A ruthenium(II) polypyridyl complex disrupts actin cytoskeleton assembly and blocks cytokinesis. Angewandte Chemie International Edition.
- Cargo regulates clathrin-coated pit invagination via clathrin light chain phosphorylation. The Journal of Cell Biology, 217(12), 4253-4266.
- Forty years on: clathrin-coated pits continue to fascinate. Molecular Biology of the Cell, 28(7), 843-847.
- Phosphoinositide acyl chain saturation drives CD8+ effector T cell signaling and function. Nature Immunology.