Dr Henry H. Roehl
School of Biosciences
Senior Lecturer
Level 2 Tutor
+44 114 222 2351
Full contact details
School of Biosciences
C21
Firth Court
Western Bank
Sheffield
S10 2TN
- Profile
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- 2004-present: MRC Centre for Developmental and Biomedical Genetics, University of Sheffield
- 2011-present: Senior Lecturer, University of Sheffield
- 2002-present: Lecturer, University of Sheffield
- 1997-2002: Postdoctoral Fellow, Max-Planck-Institut, Tuebingen. Research advisor: Dr. Nuesslein-Volhard
- 1994-1997: Ph.D. Genetics University of Wisconsin-Madison. Research advisor: Dr. Judith Kimble
- 1990-1994: Masters Genetics University of Wisconsin-Madison. Research advisor: Dr. Judith Kimble
- 1983-1988: B.S. Biology, Antioch College
- Research interests
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The Roehl Laboratory uses zebrafish as a model organism to study musculoskeletal development and disease.
Modelling skeletal disease in zebrafish
How do developmental signalling pathways regulate osteoblast differentiation during development and skeletal repair?
Osteoblasts in zebrafish follow the same differentiation pathway as in mammals: The runx2 genes are expressed in early skeletal precursors, followed by osterix and then finally by genes encoding bone proteins such as Osteonectin and Collagen1.
We have analysed how different signalling pathways regulate these steps during osteoblastogenesis using heatshock induction of signalling pathway components and pharmaceuticals that target individual pathways.
Our work has shed light on how stem cells differentiate in vivo and may help to develop regenerative therapies for skeletal diseases such as osteoarthritis and osteoporosis. We have also found a link between osteoblast and adipocyte differentiation in vivo that may help us to unravel the genetic origins of diseases such as diabetes and obesity.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- Expression of osterix Is Regulated by FGF and Wnt/β-Catenin Signalling during Osteoblast Differentiation. PLOS ONE, 10(12). View this article in WRRO
- A bi-modal function of Wnt signalling directs an FGF activity gradient to spatially regulate neuronal differentiation in the midbrain.. Development, 141(1), 63-72.
All publications
Journal articles
- Tetraspanin Cd9b and Cxcl12a/Cxcr4b have a synergistic effect on the control of collective cell migration. PLoS ONE, 16(11). View this article in WRRO
- Clinical pathologies of bone fracture modelled in zebrafish. Disease Models & Mechanisms, 12(9), dmm037630-dmm037630.
- Damage-induced reactive oxygen species enable zebrafish tail regeneration by repositioning of Hedgehog expressing cells. Nature Communications, 9(1). View this article in WRRO
- Linking wound response and inflammation to regeneration in the zebrafish larval fin.. The International Journal of Developmental Biology, 62(6-8), 473-477. View this article in WRRO
- Expression of osterix Is Regulated by FGF and Wnt/β-Catenin Signalling during Osteoblast Differentiation. PLOS ONE, 10(12). View this article in WRRO
- A bi-modal function of Wnt signalling directs an FGF activity gradient to spatially regulate neuronal differentiation in the midbrain.. Development, 141(1), 63-72.
- Loss of function of parathyroid hormone receptor 1 induces Notch-dependent aortic defects during zebrafish vascular development.. Arterioscler Thromb Vasc Biol, 33(6), 1257-1263.
- View this article in WRRO
- HSPG-deficient zebrafish uncovers dental aspect of multiple osteochondromas. PLoS ONE, 7(1). View this article in WRRO
- Differentiated skeletal cells contribute to blastema formation during zebrafish fin regeneration. Development, 138(18), 3897-3905.
- Regulation of Zebrafish Hatching by Tetraspanin cd63, 6. View this article in WRRO
- Ret signalling integrates a craniofacial muscle module during development. Development, 138(10), 2015-2024.
- Regulation of zebrafish hatching by tetraspanin cd63.. PLoS One, 6(5), e19683. View this article in WRRO
- Discovery of 6-substituted indole-3-glyoxylamides as lead antiprion agents with enhanced cell line activity, improved microsomal stability and low toxicity.. Eur J Med Chem, 46(9), 4125-4132.
- Hedgehog signalling is required for perichondral osteoblast differentiation in zebrafish.. Mech Dev, 128(1-2), 141-152.
- Shop talk: Sugars, bones, and a disease called multiple hereditary exostoses.. Dev Dyn, 239(6), 1901-1904.
- Regulation of neural crest cell fate by the retinoic acid and Pparg signalling pathways.. Development, 137(3), 389-394.
- Ret tyrosine kinase signalling is required for the development of a functionally related set of zebrafish head muscles. MECHANISMS OF DEVELOPMENT, 126, S161-S161.
- Tracking gene expression during zebrafish osteoblast differentiation. Developmental Dynamics, 238(3), spcone-spcone.
- Tracking gene expression during zebrafish osteoblast differentiation.. Dev Dyn, 238(2), 459-466.
- montalcino, A zebrafish model for variegate porphyria. Experimental Hematology, 36(9), 1132-1142.
- The multidomain protein Brpf1 binds histones and is required for Hox gene expression and segmental identity. DEVELOPMENT, 135(11), 1935-1946.
- Regulation of zebrafish skeletogenesis by ext2/dackel and papst1/pinscher.. PLoS Genet, 4(7), e1000136. View this article in WRRO
- Conserved functions of Ikaros in vertebrate lymphocyte development: Genetic evidence for distinct larval and adult phases of T cell development and two lineages of B cells in zebrafish. Journal of Immunology, 177(4), 2463-2476.
- Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis. Nature, 436(7053), 1035-1039.
- beamter/deltaC and the role of Notch ligands in the zebrafish somite segmentation, hindbrain neurogenesis and hypochord differentiation. Developmental Biology, 286(2), 391-404.
- Integrinα5 and delta/notch signaling have complementary spatiotemporal requirements during zebrafish somitogenesis. Developmental Cell, 8(4), 575-586.
- Mutations in cadherin 23 affect tip links in zebrafish sensory hair cells, 428, 955-959.
- The chianti zebrafish mutant provides a model for erythroid-specific disruption of transferrin receptor 1. Development, 131(24), 6225-6235.
- The deafness gene dfna5 is crucial for ugdh expression and HA production in the developing ear in zebrafish. Development, 131(4), 943-951.
- Axon sorting in the optic tract requires HSPG synthesis by ext2 (dackel) and extl3 (boxer). Neuron, 44(6), 947-960.
- Fgf3 signaling from the ventral diencephalon is required for early specification and subsequent survival of the zebrafish adenohypophysis. Development, 131(15), 3681-3692.
- Slb/Wnt11 controls hypoblast cell migration and morphogenesis at the onset of zebrafish gastrulation. Development, 130(22), 5375-5384.
- A zebrafish homologue of the chemokine receptor Cxcr4 is a germ-cell guidance receptor. Nature, 421(6920), 279-282.
- Analysis of a zebrafish VEGF receptor mutant reveals specific disruption of angiogenesis. Current Biology, 12(16), 1405-1412.
- Zebrafish pea3 and erm are general targets of FGF8 signaling. Current Biology, 11(7), 503-507.
- A radiation hybrid map of the zebrafish genome. Nature Genetics, 23(1), 86-89.
- The origin and evolution of animal appendages. Proceedings of the National Academy of Sciences of the United States of America, 94(10), 5162-5166.
- Roles of the RAM and ANK domains in signaling by the C.elegans GLP-1 receptor. EMBO Journal, 15(24), 7002-7012.
- Control of cell fate in C. elegans by a GLP-1 peptide consisting primarily of ankyrin repeats. Nature, 364(6438), 632-635.
Conference proceedings papers
- FGF signalling is regulating bone development in zebrafish. MECHANISMS OF DEVELOPMENT, Vol. 126 (pp S209-S209)
- Mandibular arch muscle identity is regulated by a conserved molecular process during vertebrate development. JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION, Vol. 310B(4) (pp 355-369)
- Expression of osterix Is Regulated by FGF and Wnt/β-Catenin Signalling during Osteoblast Differentiation. PLOS ONE, 10(12). View this article in WRRO
- Research group
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PhD studentship opportunities
We advertise PhD opportunities (Funded or Self-Funded) on FindAPhD.com
- Grants
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- Cancer Research UK
- Medical Research Council
- HEFC
- Teaching activities
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Undergraduate
- BMS109-106 Pathobiology
- BMS109 Cell & Molecular
- BMS242/243 Cell & Molecular
- Level 3 Practical and Dissertation Modules