Dr Lynda Partridge

School of Biosciences

Senior Lecturer

Dr Lynda Partridge
l.partridge@sheffield.ac.uk
+44 114 222 4185

Full contact details

Dr Lynda Partridge
School of Biosciences
Firth Court
Western Bank
Sheffield
S10 2TN
Profile

I am a Senior Lecturer in the School of Biosciences and teach Immunology to students in all years of our course. After a Biological Sciences degree at the University of Birmingham (specialising in Microbiology and Genetics) I carried out my PhD in Immunology at the Medical School there. I moved to Sheffield as a postdoctoral worker and later joined the Department as a lecturer. Most of my research now focusses on the tetraspanin family of membrane proteins and their role in infection, but I also have a long-standing interest in the application of antibody techniques to research and medicine.  I’m currently Chair of the Yorkshire Branch of the Royal Society of Biology and am a Fellow of the Royal Society of Biology.

Career history

  • 1979-1982: PhD, Department of Immunology, University of Birmingham
  • 1882-1988: Post-doctoral researcher, Department of Biochemistry University of Sheffield
  • 1988-1998: Lecturer, Department of Molecular Biology and Biotechnology, University of Sheffield
  • 1990, 1993: Visiting Researcher, Scripps Research Clinic, La Jolla, California
  • 2009-2013: Scientific Director, Bioserv UK Ltd.
  • 1998-present: Senior Lecturer, School of Biosciences, University of Sheffield

 

Qualifications
  • PhD Immunology (University of Birmingham)
  • MSc Immunology (University of Birmingham)
  • BSc Biological Sciences (University of Birmingham)
Research interests

Tetraspanins in health and disease

Tetraspanins are a highly conserved superfamily of transmembrane proteins, with the first member having appeared some 570 million years ago! They are widely expressed in multicellular organisms and are involved in basic cell functions such as motility, fusion and membrane trafficking. Tetraspanins form promiscuous associations with one another and with other membrane proteins and lipids to generate a specialised type of microdomain: the tetraspanin enriched microdomain (TEM). There are 33 tetraspanins in mammals with roles in fertility, the immune response, cancer progression and susceptibility to infections.

Our group uses specific antibodies and other tetraspanin-based reagents to investigate how these proteins function in health and disease. We have shown that tetraspanins help control the formation of multinucleated giant cells (MNGCs), which are associated with chronic inflammation and certain types of infection, particularly those caused by viruses.

We have also discovered that many pathogenic bacteria “hijack” tetraspanin microdomains as a way of attaching to host cells before causing infection. This has encouraged us to develop tetraspanin-based reagents as alternatives to antibiotics for treating infections caused by a wide range of microbes such as Staphylococcus aureus (including MRSA).

Antibodies in research

I have also had a long-standing interest in the production and use of antibodies as tools in research and medicine. In the early 1990s, I helped establish a dedicated facility at the University for Custom Production of antibodies for researchers. A related spinout company, Bioserv UK Ltd, established in 2009, specialises in the production of antibodies and other proteins from mammalian cell culture.

Publications

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Journal articles

All publications

Journal articles

Conference proceedings papers

  • Hassuna N, Monk P, Read R & Partridge L (2010) The role of tetraspanin proteins in macrophage uptake of Salmonella bacteria. IMMUNOLOGY, Vol. 131 (pp 80-80) RIS download Bibtex download
  • Partridge LJ, Varadharajan P, Hulme R & Monk P (2008) Roles for tetraspanin proteins in the fusion of human monocytes to form multinucleated giant cells. IMMUNOLOGY, Vol. 125 (pp 6-7) RIS download Bibtex download
  • Scola AM, Higginbottom A, Partridge LJ & Monk PN (2007) Different ligand-binding mechanisms used by the two C5a receptors, C5L2 and C5aR. MOLECULAR IMMUNOLOGY, Vol. 44(1-3) (pp 237-237) RIS download Bibtex download
  • Blackburn GM, Rickard JH, Cesaro-Tadic S, Lagos D, Mekhalfia A, Partridge L & Pluckthun A (2004) Passive and catalytic antibodies and drug delivery. PURE AND APPLIED CHEMISTRY, Vol. 76(5) (pp 983-989) RIS download Bibtex download
  • Wong CH, Higginbottom A, Monk P, Partridge LJ & Moore HD (2001) Inhibition of sperm-oolemma interactions by the extracellular domains of CD9 and CD81. ANDROLOGY IN THE 21ST CENTURY, SHORT COMMUNICATIONS (pp 565-572) RIS download Bibtex download
  • Yazici ZA, Behrendt M, Goodfield M, Partridge LJ & Lindsey NJ (1998) Does the CDR3 of the heavy chain determine the specificity of autoantibodies in systemic lupus erythematosus?. JOURNAL OF AUTOIMMUNITY, Vol. 11(5) (pp 477-483) RIS download Bibtex download
  • McCullough B, Peppa D, Monk PN, Skubitz KM & Partridge LJ (1996) A role for CD63 in signal transduction. IMMUNOLOGY, Vol. 89 (pp OM114-OM114) RIS download Bibtex download
  • Higginbottom A, Partridge LJ & Monk PN (1996) Identification of potential ligands for CD63 from random peptide libraries. IMMUNOLOGY, Vol. 89 (pp OM117-OM117) RIS download Bibtex download
Research group

Most of my current research is focussed on the role of tetraspanins in bacterial infections. Together with colleagues in Medicine and Engineering in Sheffield and at the LV-Prasad Eye Institute in Hyderabad, I am a co-investigator on an MRC GCRF-funded project that aims to develop new anti-adhesive treatments for infections that cause corneal ulceration and blindness. With colleagues in Medicine in Sheffield and Mahidol University in Bangkok, we have also been investigating the role of tetraspanins in the tropical disease melioidosis. I currently supervise three PhD students as primary supervisor and two as secondary supervisor.

Teaching activities

Level 4 modules

  • MBB405 Advanced Research Topics

Level 3 modules

  • MBB311 Molecular Immunology (Module Coordinator)

Level 2 modules

  • MBB263 Microbiology 2

Level 1 modules

  • MBB163 Microbiology
Professional activities

I am Chair of the Yorkshire Branch of Royal Society of Biology, represent the Sheffield region for the British Society of Immunology, and am a Fellow of the Royal Society of Biology.