Dr Rebecca Corrigan

School of Biosciences

Senior Lecturer

Dr Rebecca Corrigan
r.corrigan@sheffield.ac.uk
+44 114 222 4238

Full contact details

Dr Rebecca Corrigan
School of Biosciences
Firth Court
Western Bank
Sheffield
S10 2TN
Profile

Career history

  • 2018 - present:  Lister Institute Fellowship, University of Sheffield
  • 2015 – present: Royal Society/ Wellcome Trust Sir Henry Dale Research Fellow, University of Sheffield, UK
  • 2008 – 2014: Postdoctoral Research Associate, Imperial College London, UK
  • 2004 – 2008: PhD, Trinity College Dublin, Ireland
Research interests

My research involves an in-depth characterisation of nucleotide signalling systems in the Gram-positive pathogen Staphylococcus aureus. S. aureus is a human pathogen responsible for a vast array of disease and morbidity worldwide, a problem that is exacerbated by the spread of antibiotic-resistant strains such as methicillin resistant S. aureus (MRSA).

When this bacterium invades a human host it encounters a number of different stresses, such as nutrient limitation. The bacteria respond to these stresses by switching on a nucleotide signalling system called the stringent response.

This response results in the synthesis of two small nucleotides, collectively referred to as (p)ppGpp, which can be made in the cell by three different enzymes – RSH, RelP and RelQ. These nucleotides are the effectors of the stringent response and function by binding to target proteins leading to the bacterial cells shutting down active growth and entering a persistent state that promotes survival.

My previous research has led to the development of a genome-wide approach to analyse nucleotide-protein interactions. The current focus of the lab is on utilising this methodology, in conjunction with biochemical assays, to identify binding targets for (p)ppGpp in S. aureus in order to precisely map how these nucleotides function in a bacterial cell.

By mapping of the (p)ppGpp signalling network this research will provide key insights into the functioning of (p)ppGpp and so generate important mechanistic data on the pathogenesis of S. aureus.

Publications

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Journal articles

Conference proceedings papers

Research group

PhD studentships

Funded PhD studentships will be advertised here as they become available but well qualified graduates, including those intending to self fund, should contact me directly to discuss possible projects.

Examples of potential projects could include the molecular characterisation of a nucleotide-protein interaction in vitro and the elucidation of the importance of this interaction for bacterial virulence in vivo.

You can apply for a PhD position in MBB here.

Postdoctoral fellowships

Postdocs who wish to apply for a fellowship to join the group are more than welcome. Please contact me directly to discuss potential projects.

Project students and internships

Students wishing to apply for summer internships are welcome and should send a CV describing their motivations and interests.

Teaching activities

Level 1 modules

MBB163 Microbiology

Level 2 modules

MBB267 Genes, genomes and chromosomes

Level 3 modules

MBB323 Microbial Structure and Dynamics: Genes and Populations

Level 4 modules

MBB409 Infectious Disease and Antimicrobials