Dr Stephen Brown

All publications

Journal articles

• Hadianamrei R, Tomeh MA, Wang J, Brown S & Zhao X (2023) Surfactant like peptides for targeted gene delivery to cancer cells. Biochemical and Biophysical Research Communications.
• Hough J, Howard JD, Brown S, Portwood DE, Kilby PM & Dickman MJ (2022) Strategies for the production of dsRNA biocontrols as alternatives to chemical pesticides. Frontiers in Bioengineering and Biotechnology, 10. View this article in WRRO
• Howard JD, Beghyn M, Dewulf N, De Vos Y, Philips A, Portwood D, Kilby PM, Oliver D, Maddelein W, Brown S & Dickman MJ (2022) Chemically-modified dsRNA induces RNAi effects in insects in vitro and in vivo: A potential new tool for improving RNA-based plant protection.. Journal of Biological Chemistry, 102311-102311.
• Tomeh MA, Hadianamrei R, Xu D, Brown S & Zhao X (2022) Peptide-functionalised magnetic silk nanoparticles produced by a swirl mixer for enhanced anticancer activity of ASC-J9. Colloids and Surfaces B: Biointerfaces, 216.
• Hadianamrei R, Wang J, Brown S & Zhao X (2022) Rationally designed cationic amphiphilic peptides for selective gene delivery to cancer cells. International Journal of Pharmaceutics, 617.
• Hadianamrei R, Anas Tomeh M, Brown S, Wang J & Zhao X (2022) Rationally designed short cationic α-helical peptides with selective anticancer activity. Journal of Colloid and Interface Science, 607(Part 1), 488-501. View this article in WRRO
• Cirillo S, Tomeh MA, Wilkinson RN, Hill C, Brown S & Zhao X (2021) Designed antitumor peptide for targeted siRNA delivery into cancer spheroids. ACS Applied Materials & Interfaces, 13(42), 49713-49728. View this article in WRRO
• Hadianamrei R, Tomeh MA, Brown S, Wang J & Zhao X (2021) Correlation between the secondary structure and surface activity of β-sheet forming cationic amphiphilic peptides and their anticancer activity. Colloids and Surfaces B: Biointerfaces, 209(Part 2). View this article in WRRO
• Anas Tomeh M, Hadianamrei R, Sun W, Xu D, Brown S & Zhao X (2021) Stiffness-tuneable nanocarriers for controlled delivery of ASC-J9 into colorectal cancer cells. Journal of Colloid and Interface Science, 594, 513-521. View this article in WRRO
• Carmell N, Rominiyi O, Myers KN, McGarrity-Cottrell C, Vanderlinden A, Lad N, Perroux-David E, El-Khamisy SF, Fernando M, Finegan KG , Brown S et al (2021) Identification and validation of ERK5 as a DNA damage modulating drug target in glioblastoma. Cancers, 13(5). View this article in WRRO
• Naumovska E, Aalderink G, Wong Valencia C, Kosim K, Nicolas A, Brown S, Vulto P, Erdmann KS & Kurek D (2020) Direct on-chip differentiation of intestinal tubules from induced pluripotent stem cells. International Journal of Molecular Sciences, 21(14). View this article in WRRO
• Walters K, Sarsenov R, Too WS, Hare RK, Paterson IC, Lambert DW, Brown S & Bradford JR (2019) Comprehensive functional profiling of long non-coding RNAs through a novel pan-cancer integration approach and modular analysis of their protein-coding gene association networks. BMC Genomics, 20(1), ---. View this article in WRRO
• Carmell N, Brown S, Khamisy S & Collis S (2018) NOVEL DRUG TARGETS TO AUGMENT TEMOZOLOMIDE SENSITIVITY IN HIGH-GRADE BRAIN TUMOURS. Neuro-Oncology, 20(suppl_5), v346-v346.
• Fisher KH, Fragiadaki M, Pugazhendhi D, Bausek N, Arredondo MA, Thomas SJ, Brown S & Zeidler MP (2018) A genome-wide RNAi screen identifies MASK as a positive regulator of cytokine receptor stability.. Journal of Cell Science, 131(13), 0-0. View this article in WRRO
• Balasubramanian M, Hurst J, Brown S, Bishop NJ, Arundel P, DeVile C, Pollitt RC, Crooks L, Longman D, Caceres JF , Shackley F et al (2017) Compound heterozygous variants in NBAS as a cause of atypical osteogenesis imperfecta.. BONE, 94, 65-74. View this article in WRRO
• Fisher KH, Stec W, Brown S & Zeidler MP (2016) Mechanisms of JAK/STAT pathway negative regulation by the short coreceptor Eye Transformer/Latran. Molecular Biology of the Cell, 27(3), 421-598. View this article in WRRO
• Brown S (2015) Applied RNAi. From Fundamental Research to Therapeutic Applications. Edited by Patrick Arbuthnot and Marc S. Weinberg. ChemMedChem, 10(11), 1934-1935.
• Thomas S, Fisher KH, Snowden JA, Danson SJ, Brown S & Zeidler MP (2015) Methotrexate Is a JAK/STAT Pathway Inhibitor. PLoS ONE, 10(7), ---. View this article in WRRO
• Thomas S, Fisher K, Snowden J, Danson S, Brown S & Zeidler M (2015) Effect of methotrexate on JAK/STAT pathway activation in myeloproliferative neoplasms. The Lancet, 385, S98-S98.
• Lowe N, Rees JS, Roote J, Ryder E, Armean IM, Johnson G, Drummond E, Spriggs H, Drummond J, Magbanua JP , Naylor H et al (2014) Analysis of the expression patterns, subcellular localisations and interaction partners of Drosophila proteins using a pigP protein trap library. Development, 141(20), 3994-4005.
• Ivatt RM, Sanchez-Martinez A, Godena VK, Brown S, Ziviani E & Whitworth AJ (2014) Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy. Proceedings of the National Academy of Sciences, 111(23), 8494-8499.
• Brown S (2014) The Sheffield RNAi Screening Facility (SRSF): Portfolio Growth and Technology Development. Combinatorial Chemistry & High Throughput Screening, 17(4), 319-321.
• Brown S (2012) Putting the 'fun' into functional genomics: A review of RNAi genomewide cellular screens. European Pharmaceutical Review, 17(6).
• Fisher KH, Wright VM, Taylor A, Zeidler MP & Brown S (2012) Advances in genome-wide RNAi cellular screens: a case study using the Drosophila JAK/STAT pathway. BMC Genomics, 13(1). View this article in WRRO
• Brown S (2010) Institutional Profile: The Sheffield RNAi screening facility: a service for high-throughput, genome-wide Drosophila RNAi screens. Future Medicinal Chemistry, 2(12), 1805-1812.
• Brown S & Zeidler MP (2008) Unphosphorylated STATs go nuclear. Current Opinion in Genetics & Development, 18(5), 455-460.
• Brown ST & Nurse CA (2008) Induction of HIF-2α is dependent on mitochondrial O₂ consumption in an O₂-sensitive adrenomedullary chromaffin cell line. American Journal of Physiology-Cell Physiology, 294(6), C1305-C1312.
• Engsontia P, Sanderson AP, Cobb M, Walden KKO, Robertson HM & Brown S (2008) The red flour beetle's large nose: An expanded odorant receptor gene family in Tribolium castaneum. Insect Biochemistry and Molecular Biology, 38(4), 387-397.
• Buttigieg J, Brown ST, Lowe M, Zhang M & Nurse CA (2008) Functional mitochondria are required for O₂but not CO₂sensing in immortalized adrenomedullary chromaffin cells. American Journal of Physiology-Cell Physiology, 294(4), C945-C956.
• Buttigieg J, Brown ST, Zhang M & Nurse CA (2008) Does chronic stimulation of both nicotinic and opioid receptors contribute to the loss of O2 and CO2 sensitivity in perinatal adrenomedullary chromaffin cells?. The FASEB Journal, 22(S1).
• Piskuric NA, Brown ST & Nurse CA (2008) Role of ATP‐sensitive K ⁺ channels in glucose sensing by immortalized adrenomedullary chromaffin cells. The FASEB Journal, 22(S1).
• Gregory L, Came PJ & Brown S (2008) Stem cell regulation by JAK/STAT signaling in Drosophila. Seminars in Cell & Developmental Biology, 19(4), 407-413.
• Watson CJ & Brown S (2008) Editorial. Seminars in Cell & Developmental Biology, 19(4), 309-310.
• Brown S, Zeidler MP & Hombría JEC-G (2006) JAK/STAT signalling inDrosophila controls cell motility during germ cell migration. Developmental Dynamics, 235(4), 958-966.
• Hombría JC-G, Brown S, Häder S & Zeidler MP (2005) Characterisation of Upd2, a Drosophila JAK/STAT pathway ligand. Developmental Biology, 288(2), 420-433.
• Denholm B, Brown S, Ray RP, Ruiz-Gómez M, Skaer H & Hombría JC-G (2005) crossveinless-cis a RhoGAP required for actin reorganisation during morphogenesis. Development, 132(10), 2389-2400.
• BROWN S, JOHNSON R, SENARATNE R & FEARON I (2004) Amyloid ? peptides mediate physiological remodelling of the acute O sensitivity of adrenomedullary chromaffin cells following chronic hypoxia. Cardiovascular Research, 64(3), 536-543.
• Fearon IM & Brown ST (2004) Acute and chronic hypoxic regulation of recombinant hNav1.5 α subunits. Biochemical and Biophysical Research Communications, 324(4), 1289-1295.
• Hudasek K, Brown ST & Fearon IM (2004) H2O2 regulates recombinant Ca2+ channel α1C subunits but does not mediate their sensitivity to acute hypoxia. Biochemical and Biophysical Research Communications, 318(1), 135-141.
• Brown S, Hu N & Hombría JC-G (2003) Novel level of signalling control in the JAK/STAT pathway revealed by in situ visualisation of protein-protein interaction during Drosophiladevelopment. Development, 130(14), 3077-3084.
• Hombrı́a JC-G & Brown S (2002) The Fertile Field of Drosophila JAK/STAT Signalling. Current Biology, 12(16), R569-R575.
• Brown S, Hu N & Hombrı́a JC-G (2001) Identification of the first invertebrate interleukin JAK/STAT receptor, the Drosophila gene domeless. Current Biology, 11(21), 1700-1705.
• Brown S & Castelli-Gair Hombria J (2000) Drosophila grain encodes a GATA transcription factor required for cell rearrangement during morphogenesis. Development, 127(22), 4867-4876.
• Hamilton AJ, Brown S, Yuanhai H, Ishizuka M, Lowe A, Solis A-GA & Grierson D (1998) A transgene with repeated DNA causes high frequency, post-transcriptional suppression of ACC-oxidase gene expression in tomato. The Plant Journal, 15(6), 737-746.
• Payton S, Fray RG, Brown S & Grierson D (1996) Ethylene receptor expression is regulated during fruit ripening, flower senescence and abscission. Plant Molecular Biology, 31(6), 1227-1231.

Chapters

• Fisher KH, Brown S & Zeidler MP (2013) Designing RNAi Screens to Identify JAK/STAT Pathway Components, Methods in Molecular Biology (pp. 81-97). Humana Press

Conference proceedings papers

• Valencia CEW & Brown S (2017) Generation of a model of iPSC-derived human intestinal organoids. HUMAN GENE THERAPY, Vol. 28(8) (pp A26-A26)
• Thomas SJ, Fisher K, Brown S, Snowden JA, Danson S & Zeidler M (2014) Methotrexate Is a Suppressor of JAK/STAT Pathway Activation Which Inhibits JAK2V617F Induced Signalling. Blood, Vol. 124(21) (pp 4577-4577)
• Nurse CA, Buttigieg J, Brown S & Holloway AC (2009) Regulation of Oxygen Sensitivity in Adrenal Chromaffin Cells. Annals of the New York Academy of Sciences, Vol. 1177(1) (pp 132-139)
• Brown S, Smythe E, Strutt D, Whitworth A & Zeidler M (2009) 18-P019 The University of Sheffield RNAi Screening facility: Genome-wide RNAi screens in Drosophila cells using a 2nd generation in silico optimized library. Mechanisms of Development, Vol. 126 (pp S290-S290)
• FEARON IM, CAMPANUCCI VA, BROWN ST, HUDASEK K, O’KELLY IM & NURSE CA () Acute Hypoxic Regulation of Recombinant THIK-1 Stably Expressed in HEK293 Cells (pp 203-208)

Preprints

• Howard JD, Beghyn M, Dewulf N, De Vos Y, Philips A, Portwood D, Kilby PM, Oliver D, Maddelein W, Brown S & Dickman MJ () Chemically modified dsRNA induces RNAi effects in insects in vitro and in vivo: A potential new tool for improving RNA-based plant protection, Cold Spring Harbor Laboratory.
• Walters K, Sarsenov R, Too WS, Hare RK, Paterson IC, Lambert DW, Brown S & Bradford JR () Comprehensive functional profiling of long non-coding RNAs through a novel pan-cancer integration approach and modular analysis of their protein-coding gene association networks, Cold Spring Harbor Laboratory.
• Fisher KH, Fragiadaki M, Pugazhendhi D, Bausek N, Brown S & Zeidler MP () A genome-wide RNAi screen identifies MASK as a positive regulator of cytokine receptor stability, Cold Spring Harbor Laboratory.