Structural Biology

Exploring the architecture and interactions of biological systems in atomic detail.

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In the structural biology theme, we combine Cryo electron microscopy with X-ray crystallography and NMR to explore the structure of macromolecules at the highest level of atomic detail.

The dynamic behaviour of proteins in solution and how they assemble into their complex folds is explored, with particular emphasis on protein mis-folding in disease states such as Alzheimer's, on toxins from pathogenic bacteria and on photosynthetic structures.

Cryo electron tomography is used to visualise biological assemblies and processes directly in vivo. Such large datasets require expertise in computational biology to analyse and interpret results.


Recent research highlights


People

For further information and research opportunities, please see the staff page of individual researchers below:


Research institutes

Our research on Structural Biology is supported by and feeds into the following University Research Institutes.

Flagship institutes

The University’s four flagship institutes bring together our key strengths to tackle global issues, turning interdisciplinary and translational research into real-world solutions.