Dr Stephen Brown
Room: Alfred Denny B2 223
Brief career history:
Functional genomics, siRNA genome screens, drug screening, cell models of Human disease.
Functional Genomics and RNAi Screening
I have managed over 50 RNAi library screens for both UK and international scientists. My laboratory uses both automation (robotics) and molecular cell biology to identify genes involved in disease. I am also involved in teaching Masters and PhD students in the art of “Functional Genomics”.
Undergraduate and postgraduate taught modules
Postgraduate studentship opportunities
We advertise PhD opportunities (Funded or Self-Funded) on FindAPhD.com
For further information and details of other projects on offer, please see the department PhD Opportunities page:
- Direct on-chip differentiation of intestinal tubules from induced pluripotent stem cells. International Journal of Molecular Sciences, 21(14). View this article in WRRO
- Comprehensive functional profiling of long non-coding RNAs through a novel pan-cancer integration approach and modular analysis of their protein-coding gene association networks. BMC Genomics, 20(1). View this article in WRRO
- A genome-wide RNAi screen identifies MASK as a positive regulator of cytokine receptor stability.. Journal of Cell Science, 131(13). View this article in WRRO
- Compound heterozygous variants in NBAS as a cause of atypical osteogenesis imperfecta.. BONE, 94, 65-74. View this article in WRRO
- Mechanisms of JAK/STAT pathway negative regulation by the short coreceptor Eye Transformer/Latran. Molecular Biology of the Cell, 27(3), 421-598. View this article in WRRO
- Methotrexate Is a JAK/STAT Pathway Inhibitor. PLOS ONE, 10(7). View this article in WRRO
- Effect of methotrexate on JAK/STAT pathway activation in myeloproliferative neoplasms. The Lancet, 385, S98-S98.
- Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy. Proceedings of the National Academy of Sciences, 111(23), 8494-8499.
- The Sheffield RNAi Screening Facility (SRSF): Portfolio Growth and Technology Development. Combinatorial Chemistry & High Throughput Screening, 17(4), 319-321.