Dr Mirna Mustapha
MRC Senior Fellow
Room: B1 224 Alfred Denny building
Deafness is a common health problem
Hearing impairment is the most frequently occurring sensorineural defect in humans. The sense of hearing originates in the cochlea, a structure in the inner ear. Information about timing, frequency, and intensity of sounds is transmitted from the hair cells in the cochlea to the brain via spiral ganglion neurons by converting sound waves into nerve impulses. Any disruptions in this sensory pathway could result in auditory neuropathy and hearing impairment.
Exploration of the genetic differences between subtypes of type I SGNs
During development, each SGNs type I adopts specific morphological, molecular, and electrophysiological proprieties to enable them to interpret and transmit complex sounds stimuli. Recent studies suggest that different subtypes of type I SGNs differ in their vulnerability to age and/or noise induced degeneration or auditory neuropathy.
While this local heterogeneity is an important feature of the type I SGNs, it is still unclear whether it is determined by endogenous or exogenous factors. Our research aims to identity and investigate genes that define and maintain the functional heterogeneity of these different subtypes using single cell transcriptome analysis.
SCHEMATIC REPRESENTATION OF EXPERIMENTAL APPROACHES
Image by Stacy Levichev
Details about the Mustapha lab group will be along shortly.
We are currently offering a POSTDOCTORAL POSITION
More information to follow.
- Sundaresan S, Kong JH, Fang Q, Salles F, Wangsawihardja F, Ricci AJ, Mustapha M. Thyroid hormone is required for pruning, functioning and long-term maintenance of afferent inner hair cell synapses. Eur J Neurosci. 2015 Sep 19. doi:10.1111/ejn.13081. PubMed PMID: 26386265.
- Fang Q, Indzhykulian AA, Mustapha M, Riordan GP, Dolan DF, Friedman TB, Belyantseva IA, Frolenkov GI, Camper SA, Bird JE. The 133-kDa N-terminal domain enables myosin 15 to maintain mechanotransducing stereocilia and is essential for hearing. Elife. 2015 Aug 24;4. doi: 10.7554/eLife.08627. PubMed PMID: 26302205.
- Calton MA, Lee D, Sundaresan S, Mendus D, Leu R, Wangsawihardja F, Johnson KR, Mustapha M. A lack of immune system genes causes loss in high frequency hearing but does not disrupt cochlear synapse maturation in mice. PLoS One. 2014 May 7;9(5):e94549. doi: 10.1371/journal.pone.0094549. eCollection 2014. PubMed PMID: 24804771; PMCID: PMC4012943.
- Mendus D, Sundaresan S, Grillet N, Wangsawihardja F, Leu R, Müller U, Jones SM, Mustapha M. Thrombospondins 1 and 2 are important for afferent synapse formation and function in the inner ear. Eur J Neurosci. 2014 Apr;39(8):1256-67. doi: 10.1111/ejn.12486. Epub 2014 Jan 27. PubMed PMID: 24460873; PMC4132060.