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Facilities and services

We have a wide range of world-class facilities and expertise available within the department. On this page you will find information on how these facilities are used in our pioneering research. Many of these facilities are available for you to book and you can explore this in more detail by visiting the individual facility pages.

Atomic Force Microscopy (AFM) Facility

Our AFM facility includes two Bruker Multimode VIII AFMs capable of topographic, nanomechanical and nanoelectrical (electron tunnelling) imaging at nanometre resolution under liquid or in air.

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Biomolecular Interaction Suite

The suite comprises two TA instruments Isothermal Calorimetry (ITC) instruments, particularly suited to those looking at molecular interactions between purified components, and one Nanotemper Microscale Thermophoresis (MT) instrument, which can measure binding constants with one of the ligands present in a complex mixture such as a cell lysate.

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Biological Mass Spectrometry Facility

Recent developments in mass spectrometry instrumentation have revolutionised the biochemists toolkit; allowing unprecedented protein expression profiling whilst at the same time allowing traditional assays akin to western blotting to be performed with unrivalled specificity using selected reaction monitoring assays. Our full range of equipment and software includes mass spectrometry instruments and facilities for sample preparation.

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Biomolecular NMR Facility

Under the umbrella of the Krebs Institute, in purpose built accommodation, we have three high-field solution NMR spectrometers at 500, 600 and 800 MHz which are used for biological research. We also have experience in setting up and running a wide range of NMR experiments.

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Cryo-Electron Microscopy Facility

Our research facilities in Cryo-Electron Microscopy include electron microscopes, specimen preparation, image analysis and computing, and 2D crystallisation where crystals can be screened on our home built flow dialysis unit.

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Protein purification service

´╗┐Dr Sveta Sedeinikova is based in lab D11 (office D8b) and provides help and advice on all aspects of protein purification.

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The Wolfson Light Microscopy Facility

This facility offers a range of microscopes, including confocal (scanning and spinning disc), wide-field and deconvolution microscopes. There are also two super-resolution light microscopes, one based on structured illumination, another on localisation microscopy and a light sheet microscope.

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X-ray Crystallography Facility

A suite of protein crystallography laboratories, featuring robotic crystallization, dedicated crystal storage, automated crystal viewing, state of the art X-ray data collection facilities, high speed data processing and molecular graphics complements our fully specified molecular biology and protein purification laboratory, where the biological samples to be studied are prepared.

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