Simon FosterProfessor Simon Foster

Professor of Molecular Microbiology
Faculty Director of Research and Innovation


Tel: 0114 222 4411
Email: s.foster@sheffield.ac.uk

Research

Research Precis

fig1I have worked for over 20 years on the molecular physiology of Staphylococcus aureus (S. aureus), a major cause of death and disease in humans. The spread of antibiotic resistance (MRSA, VRSA) highlights its importance. Research has concentrated on a number of areas including stress responses, vaccine development, essential genes, host-pathogen interaction and cell wall architecture/dynamics. The research spans from fundamental biology to the discovery and development of targets for novel therapy and prophylaxis.  Research in my laboratory centres on two main themes associated with bacterial molecular physiology: 

1. How S. aureus interacts with its host.

In particular we have been determining the role of human innate defences in the control of S. aureus. We have also identified a number of potential novel targets to be exploited as vaccine components. The role and use of these for prophylaxis are the subject of current investigations. 

2. Bacterial cell wall structure and function.

The cell wall peptidoglycan is essential for the life of most bacteria and its synthesis is the target of important antibiotics such as penicillin and vancomycin. We are using atomic force microscopy and other super-resolution microscopy techniques to determine the architecture and dynamics of peptidoglycan across the bacteria. This has revealed a hitherto unexpected complexity leading to new models of cell wall growth and division.Research in my laboratory centres on 2 main themes associated with bacterial molecular physiology:

fig2

Research Keywords

Microbiology, Staphylococcus aureus, pathogenicity, cell wall structure

Teaching

Level 3 Modules

MBB323 Microbial Structure and Dynamics: Genes and Populations (Module Coordinator)
MBB335 Bacterial Pathogenicity

Career History

Career History

  • 1999 - present: Professor of Molecular Microbiology, University of Sheffield
  • 1993 - 2002: Royal Society University Research Fellow, University of Sheffield
  • 1990 - 1993: J.G. Graves Medical Research Fellow, University of Sheffield
  • 1986 - 1990: Broodbank Fellow, University of Cambridge
  • 1984 - 1986: PhD, University of Cambridge
  • 1983 - 1984: PhD, University of Leeds








































Publications

Journal articles

Chapters

Conference proceedings papers

  • Hobbs JK, Burns JM, Turner RD, Bailey RG, Kumar S, Tank RK, Mullin N & Foster SJ (2017) Cell wall architecture and the development of cell shape in S. aureus and E. coli. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, Vol. 46 (pp S100-S100) View this article in WRRO RIS download Bibtex download
  • Lemonche LP, Kumar S, Turner RD, Burns JM, Mullin N, Tank RK, Owen DS, Foster SJ & Hobbs JK (2017) Death or alive? Correlating the cell wall structure of sacculi and living bacteria using AFM. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, Vol. 46 (pp S295-S295) RIS download Bibtex download
  • Burns JM, Bailey RG, Kumar S, Turner RD, Mullin N, Foster SJ & Hobbs JK (2017) High resolution atomic force microscopy of living S. aureus bacterial cell wall. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, Vol. 46 (pp S291-S291) RIS download Bibtex download
  • Kumar S, Mullin N, Cartron ML, Leggett GJ, Foster SJ, Hunter CN & Hobbs JK (2017) High-resolution Atomic Force Microscopy (AFM) imaging of native biological membrane systems. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, Vol. 46 (pp S368-S368) RIS download Bibtex download
  • Dickinson R, Thompson A, Thomson J, Murphy F, Marriott H, Tavares A, Willson J, Williams L, Lewis A, Forbes S, Stimson R, Hameed A, Preston J, Lawrie A, Finisguerra V, Mazzone M, Foster S, Chilvers E, Cowburn A, Dockrell D, Johnson R, Meehan R, Whyte M & Walmsley S (2016) S104 Hypoxia preconditions the innate immune response to acute bacterial pulmonary infections. Thorax, Vol. 71(Suppl 3) (pp A61.2-A62) RIS download Bibtex download
  • Walther CG, Vahldieck M, Robinson D & Foster S (2015) New green emitting fluorochromes for Fluorescence Microscopy, specifically Structured Illumination Microscopy. Microscopy Microscience Congress 2015 (MMC 2015) (pp P2608-P2608). Manchester, 29 June 2015 - 2 July 2015. RIS download Bibtex download
  • Thompson AAR, Marriott HM, Williams L, Shaw G, Hameed A, Parmar S, Preston JA, Simon MC, Johnson RS, Foster SJ, Dockrell DH, Whyte MK & Walmsley SR (2013) HYPOXIA INDUCES HYPOTHERMIA AND SICKNESS BEHAVIOUR IN MICE FOLLOWING SUBCUTANEOUS INJECTION OF LIVE STAPHYLOCOCCUS AUREUS. THORAX, Vol. 68 (pp A140-A140) RIS download Bibtex download
  • Bleiziffer I, Pohlentz G, McAulay K, Xia G, Hussain M, Peschel A, Foster SJ, Peters G & Heilmann C (2013) At least four glycosyltransferases are involved in the glycosylation of the plasmin-sensitive protein Pls in methicillin-resistant Staphylococcus aureus (MRSA). INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, Vol. 303 (pp 57-57) RIS download Bibtex download
  • Anwar S, Sabroe I, Foster SJ & Whyte MK (2009) SUBVERSION OF NEUTROPHIL APOPTOSIS BY STAPHYLOCOCCUS AUREUS: CONSEQUENCES FOR BACTERIAL PATHOGENESIS AND HOST DEFENCE. THORAX, Vol. 64 (pp A36-A36) RIS download Bibtex download
  • Anwar S, Prince LR, Sabroe I, Foster SJ & Whyte MK (2007) Subversion of neutrophil apoptosis by Staphylococcus aureus. THORAX, Vol. 62 (pp A114-A115) RIS download Bibtex download
  • Ruud TE, Gundersen Y, Wang JE, Foster SJ, Thiemermann C & Aasen AO (2006) Systemic petidoglycan (PegG) stimulates proinflammatory responses in synergy with lipopolysaccharide (LPS) in an in vivo and in vitro porcine model.. SHOCK, Vol. 26 (pp 32-32) RIS download Bibtex download
  • Wang YY, Myhre AE, Foster SJ, Thiermann C, Bjornland K, Aasen AO & Wang JE (2005) Peptidoglycan of S aureus induced the release of MMP-9 in human blood by degranulation of neutrophils.. SHOCK, Vol. 23 (pp 76-77) RIS download Bibtex download
  • Agren J, Foster SJ, Thiemermann C, Wang JE & Aasen AO (2005) Synthetic CpG- and GpC oligonucleotides enhance the TNF alpha release induced by peptidoglycan but not by lipopolysaccharide.. SHOCK, Vol. 23 (pp 22-22) RIS download Bibtex download
  • Tarkowski A, Verdrengh M, Jonsson IM, Magnusson M, Foster SJ & Liu ZQ (2005) Carbohydrates and biology of staphylococcal infections. GLYCOBIOLOGY AND MEDICINE, Vol. 564 (pp 115-116) RIS download Bibtex download
  • Hadley JS, Wang JE, Foster SJ, Thiemermann C & Hinds CJ (2004) Cytokine responses to combined administration of lipopolysaccharide (LPS) and peptidoglycan (PepG). SHOCK, Vol. 21 (pp 50-50) RIS download Bibtex download
  • Hadley JS, Wang JE, Foster SJ, Thiemermann C & Hinds CJ (2004) Monocyte cell surface receptor upregulation in response to stimulation with lipopolysaccharide and peptidoglycan. SHOCK, Vol. 21 (pp 21-21) RIS download Bibtex download
  • Atrih A & Foster SJ (2002) Bacterial endospores the ultimate survivors. INTERNATIONAL DAIRY JOURNAL, Vol. 12(2-3) (pp 217-223) RIS download Bibtex download
  • FOSTER SJ (1994) THE ROLE AND REGULATION OF CELL-WALL STRUCTURAL DYNAMICS DURING DIFFERENTIATION OF ENDOSPORE-FORMING BACTERIA. JOURNAL OF APPLIED BACTERIOLOGY, Vol. 76 (pp S25-S39) RIS download Bibtex download