Brief career history
- 2004-present: MRC Centre for Developmental and Biomedical Genetics, University of Sheffield
- 2011-present: Senior Lecturer, University of Sheffield
- 2002-present: Lecturer, University of Sheffield
- 1997-2002: Postdoctoral Fellow, Max-Planck-Institut, Tuebingen. Research advisor: Dr. Nuesslein-Volhard
- 1994-1997: Ph.D. Genetics University of Wisconsin-Madison. Research advisor: Dr. Judith Kimble
- 1990-1994: Masters Genetics University of Wisconsin-Madison. Research advisor: Dr. Judith Kimble
- 1983-1988: B.S. Biology, Antioch College
The Roehl Laboratory uses zebrafish as a model organism to study musculoskeletal development and disease.
- Co-organiser of the EMBO 2016 Regen meeting
- Academic Editor PLoS ONE (2011- present)
- Advisor to RSPCA on manual entitled: Housing and care of aquatic species Zebrafish (2010)
- Member of the Mellanby Centre for bone research (2009-present)
- MHE Scientific Advisory Board USA (2008-present)
- Member of the MRC College of Experts (2006-2010)
- Membership in two EU funded, FW6 consortiums: ZF Models (2003-2008) and Cells to organs (2003-2009)
- Member of the Tuebingen 2000 Screen Consortium (2000-2002)
- EMBO Long-term Fellowship (1997-2000)
- NIH Postgraduate Training Fellowship (1990-1994)
- Review for Developmental Dynamics, Developmental Biology, Journal of Experimental Zoology, Current Biology, PLoS One, PLoS Genetics, Development, Biotechnology Journal, FASEB Journal.
- BSDB Committee Member
- PLoS One Academic Editor
|Invited lectures and workshops
- UK Mesenchymal Stem Cell Meeting. Birmingham, UK (1/7/11)
- Hereditary Multiple Exostoses Support Group Meeting. Liverpool, UK (26/3/11)
- Institute of Animal Technology Meeting. Sheffield, UK (8/9/10)
- Course teacher in EMBO practical course “Animal models for physiology and disease” UK (19/7/10)
- Gordon Conference Proteoglycans, Proctor Academy, Andover, NH, USA (11/7/10)
- Third International MHE/MO/HME Research Conference, Boston, USA (29/10/09)
- Bone Research Society's annual meeting. London, UK (15/06/09)
- Tissue Specification and Organogenesis. Lisbon, Portugal (6/2/09)
- Developmental Biology Seminar Series. Gurdon Institute, Cambridge UK (6/6/08)
- Society for Glycobiology annual meeting. Boston USA (12/11/07)
- Course teacher in EMBO practical course "Animal models for development, physiology and disease" UK (16/7/07)
- Craniofacial Development seminar series. KCL, London UK (11/6/07)
- Genetics and Development seminar series, LIMR, Mill Hill, UK (12/6/07)
- Gordon Conference Proteoglycans, Proctor Academy, Andover, NH, USA (11/7/06)
- IMP seminar series, Research Institute of Molecular Pathology, Vienna, AT (2/2/06)
Modelling skeletal disease in zebrafish
How do developmental signalling pathways regulate osteoblast differentiation during development and skeletal repair?
Osteoblasts in zebrafish follow the same differentiation pathway as in mammals: The runx2 genes are expressed in early skeletal precursors, followed by osterix and then finally by genes encoding bone proteins such as Osteonectin and Collagen1.
We have analysed how different signalling pathways regulate these steps during osteoblastogenesis using heatshock induction of signalling pathway components and pharmaceuticals that target individual pathways.
Our work has shed light on how stem cells differentiate in vivo and may help to develop regenerative therapies for skeletal diseases such as osteoarthritis and osteoporosis. We have also found a link between osteoblast and adipocyte differentiation in vivo that may help us to unravel the genetic origins of diseases such as diabetes and obesity.
- Cancer Research UK
- Medical Research Council
Current lab members
See: Roehl lab members