Dr Henry H. Roehl

Dr Henry RoehlSenior Lecturer
Level 2 Tutor

Department of Biomedical Science
The University of Sheffield
Sheffield S10 2TN
United Kingdom

Tel: +44 (0) 114 222 2351
Room: C21 Firth Court
Email: h.roehl@sheffield.ac.uk

Patterning & Morphogenesis Bateson Centre


Developmental Biology
Stem Cells and Regenerative Medicine
General

Brief career history

  • 2004-present: MRC Centre for Developmental and Biomedical Genetics, University of Sheffield
  • 2011-present: Senior Lecturer, University of Sheffield
  • 2002-present: Lecturer, University of Sheffield
  • 1997-2002: Postdoctoral Fellow, Max-Planck-Institut, Tuebingen. Research advisor: Dr. Nuesslein-Volhard
  • 1994-1997: Ph.D. Genetics University of Wisconsin-Madison. Research advisor: Dr. Judith Kimble
  • 1990-1994: Masters Genetics University of Wisconsin-Madison. Research advisor: Dr. Judith Kimble
  • 1983-1988: B.S. Biology, Antioch College

Research interests

The Roehl Laboratory uses zebrafish as a model organism to study musculoskeletal development and disease.

Professional activities

  • Co-organiser of the EMBO 2016 Regen meeting
  • Academic Editor PLoS ONE (2011- present)
  • Advisor to RSPCA on manual entitled: Housing and care of aquatic species Zebrafish (2010)
  • Member of the Mellanby Centre for bone research (2009-present)
  • MHE Scientific Advisory Board USA (2008-present)
  • Member of the MRC College of Experts (2006-2010)
  • Membership in two EU funded, FW6 consortiums: ZF Models (2003-2008) and Cells to organs (2003-2009)
  • Member of the Tuebingen 2000 Screen Consortium (2000-2002)
  • EMBO Long-term Fellowship (1997-2000)
  • NIH Postgraduate Training Fellowship (1990-1994)
  • Review for Developmental Dynamics, Developmental Biology, Journal of Experimental Zoology, Current Biology, PLoS One, PLoS Genetics, Development, Biotechnology Journal, FASEB Journal.
  • BSDB Committee Member
  • PLoS One Academic Editor
Invited lectures and workshops
  • 16/09/18 Session Chair: EMBO Regeneration Conference, Malta
  • 18/09/16 Invited speaker, EMBO Regeneration Conference, Paestum (Salerno), Italy
  • 09/10/14 Invited speaker, ISTT Annual Meeting, Edinburgh, Scotland
  • 03/11/12 Invited speaker, MHE Research Conference, Philadelphia, USA
  • 04/09/12 Session Chair: EMBO regeneration Conference, Oxford
  • 23/10/12 Invited speaker, European CardioCell Consortium Meeting, Mölle, Sweden
  • 01/07/11 Invited speaker, UK Mesenchymal Stem Cell Meeting, Birmingham
  • 26/03/11 Invited speaker, Hereditary Multiple Exostoses Support Group, Liverpool
  • 08/09/10 Invited speaker, Institute of Animal Technology Meeting, Sheffield
  • 19/07/10 Course teacher EMBO workshop “Animal models for physiology and disease”, UK
  • 11/07/10 Invited speaker, Gordon Conference Proteoglycans, Proctor Academy, NH, USA
  • 29/10/09 Invited speaker, Third International MHE Research Conference, USA
  • 08/07/09 Invited speaker, Schloss Ringberg Conference, Ringberg, Germany
  • 15/06/09 Invited speaker, Bone Research Society's annual meeting, London
  • 09/06/09 Invited speaker, Mellanby Centre for Bone Research - Opening Day, Sheffield
  • 02/06/09 Invited speaker, LUMC seminar series, Leiden University, The Netherlands
  • 06/02/09 Invited speaker, Tissue Specification and Organogenesis, Lisbon, Portugal
  • 06/06/08 Invited speaker, Developmental Biology Seminar Series. Gurdon Institute, Cambridge
  • 12/11/07 Invited speaker, Society for Glycobiology annual meeting. Boston USA
  • 16/07/07 Course teacher EMBO workshop “Animal models for physiology and disease”, UK
  • 11/06/07 Invited speaker, Craniofacial Development seminar series. KCL, London UK
  • 12/06/07 Invited speaker, Genetics and Development seminar series, LIMR, Mill Hill, UK
  • 11/07/06 Invited speaker, Gordon Conference Proteoglycans, Proctor Academy, NH, USA
  • 02/02/06 Invited speaker, IMP seminar series, Vienna

Full publications

Research

Modelling skeletal disease in zebrafish

How do developmental signalling pathways regulate osteoblast differentiation during development and skeletal repair?

Osteoblasts in zebrafish follow the same differentiation pathway as in mammals: The runx2 genes are expressed in early skeletal precursors, followed by osterix and then finally by genes encoding bone proteins such as Osteonectin and Collagen1.

We have analysed how different signalling pathways regulate these steps during osteoblastogenesis using heatshock induction of signalling pathway components and pharmaceuticals that target individual pathways.

Our work has shed light on how stem cells differentiate in vivo and may help to develop regenerative therapies for skeletal diseases such as osteoarthritis and osteoporosis. We have also found a link between osteoblast and adipocyte differentiation in vivo that may help us to unravel the genetic origins of diseases such as diabetes and obesity.

Figure 1

Funding

  • Cancer Research UK
  • Medical Research Council
  • HEFC

Current lab members

See: Roehl lab members

Teaching

Undergraduate and postgraduate taught modules

Undergraduate

  • BMS109-106 Pathobiology
  • BMS109 Cell & Molecular
  • BMS242/243 Cell & Molecular
  • Level 3 Practical and Dissertation Modules

Opportunities

PhD studentship opportunities

We advertise PhD opportunities (Funded or Self-Funded) on FindAPhD.com

For further information and details of other projects on offer, please see the department PhD Opportunities page:

PhD Opportunities

Selected publications

Journal articles