Facilities and services
The department provides extensive and specialist facilities for research and teaching. Key facilities and services include:
As part of the Faculty of Science Mass Spectrometry Centre, the biOMICS facility provides a wide range of mass spectrometry analyses that includes molecular identification, characterisation, post-translational modification analysis, proteomic and metabolomic profiling.
The fruit fly, Drosophila melanogaster, provides a powerful tool to study molecular and cellular mechanisms underlying animal development, physiology and ageing, and has played a crucial role in the identification of many human disease pathways. A laboratory is dedicated to servicing these experiments and includes technicians to support the breeding and feeding programs.
The EM suite comprises the Wellcome Centre for Electron Microscopy, the Structural Biology Group facility within the department of Molecular Biology and Biotechnology (MBB) and the Histology and Histochemistry laboratory within Biomedical Science.
The Electronics Workshop assists in the development, maintenance and safety of research and teaching facilities. It covers a diverse range of equipment in contemporary biomedical science.
Housed within the Centre for Stem Cell Biology, this facility provides high throughput analysis of stem cell cultures and a time lapse microscope culture laboratory that allows for detailed multi-wavelength analysis of cell proliferation and phenotype over extended times in culture.
The Wolfson Light Microscope Facility (LMF) is a Faculty of Science unit. We offer training and guidance in the use of a wide range of advanced microscopy techniques and systems. Users of all levels of expertise are catered for. We provide a range of confocal microscopes, widefield systems and image analysis software.
The Sheffield Single-Cell Omics Facility (sCOF) is a core facility of the Faculty of Science at the University of Sheffield. The single-cell approach to a scientific question allows the exploration of cellular hetereogeneity and the identification of novel cellular sub-populations in complex tissue samples.
Housed within the Bateson Centre, the Zebrafish facility has four independent zebrafish aquarium systems with a total capacity of approximately 23,000 litres. This allows a large number of research groups to undertake a diverse range of experimentation.
The Sheffield Zebrafish Screening Unit
The Sheffield Zebrafish Screening Unit provides a dedicated facility for whole-organism (zebrafish) in vivo screens for researchers that are studying a range of developmental and disease mechanisms.
The unit may also be used to identify new potential therapeutic small molecules or test drug toxicities. It supports innovative collaborations with both academic and industrial partners.
The Sheffield RNAi Screening Facility (SRSF)
The Sheffield RNAi Screening Facility provides a service for whole genome screening experiments at low cost.
In addition, the facility provides specialist equipment to assist the wider scientific community in carrying out high-throughput RNAi screens with Drosophila cells.