Host-pathogen interactions and antimicrobial resistance

We are elucidating the complex processes that define the behaviour of host/pathogen interactions, using a range of bacterial human pathogens. Understanding of and finding solutions to antimicrobial resistance is at the forefront of our research.

Drugs screening

Our research

Antibiotic resistance is a global problem which affects everyone, threatening our ability to treat common infections at an unprecedented rate. It is the responsibility of government, industry and academia to work together to minimise the further emergence and spread of antibiotic resistance. The World Health Organisation (WHO) aptly sums up this clear and present danger:

"As an academic community, we can help to combat this global challenge by gaining an in-depth understanding of the molecular mechanisms behind these pathogens. Understanding how pathogens cause infections, persist in the host, evade the immune system and transmit back to the environment will eventually culminate in new interventions which will reduce or surpass the need for traditional antibiotics. Without urgent, coordinated action, the world is heading towards a post-antibiotic era, in which common infections and minor injuries, which have been treatable for decades, can once again kill."

Sheffield has attracted a host of top-notch young scientists who have succeeded in winning prestigious fellowships from the Royal Society, Lister Institute and Wellcome Trust. Our success revolves around world-class facilities and interdisciplinary research activities within and outside Sheffield, such as Florey, Imagine and the Bateson centre.

Recent research highlights


For further information and research opportunities, please see the staff page of individual researchers below:

Research institutes

Our Research on Host-Pathogen Interactions and Antimicrobial Resistance is supported by and feeds into the following University Research Institutes.

Flagship institutes

The University’s four flagship institutes bring together our key strengths to tackle global issues, turning interdisciplinary and translational research into real-world solutions.