Systems Neuroscience

Systems Neuroscience research in Sheffield encompasses animal and human neuroimaging, in-vivo and in-vitro neurophysiological techniques, neuropharmacology and mathematical modelling.

Our research has impact in a wide range of scientific and medical fields,  including ageing and neurodegenerative diseases such as Parkinsons's disease and Alzheimer's disease, conditions such as Attention Deficit Hyperactivity Disorder and drug abuse, as well as the mechanisms underlying action selection, cerebrovascular regulation and neuroenergetics.

Our research makes connections across the different levels of description of brain function, ranging from subcellular, through to whole brain systems and behaviour. Our work forms a part of Sheffield Neuroscience.


Dr Jason Berwick

  • Understanding neurovascular coupling in health and disease
  • Understanding the negative BOLD signal
  • The use of focal cooling as a treatment for epilepsy 
  • Neurovascular breakdown in Alzheimer's disease

Dr Clare Howarth

  • Investigating how the brain's blood supply is regulated to meet the changing demands of neuronal activity, and how this may change in aging and disease
  • The role of astrocytes in supporting neurovascular coupling
  • Establishing new models to investigate neurovascular coupling

Dr Myles Jones

  • Non-invasive functional neuroimaging techniques
  • Interpreting imaging data
  • Stimulus-evoked neural activity and hemodynamics
  • “Resting-state” neuroimaging data

Dr Chris Martin

  • The roles of the neurotransmitters dopamine, serotonin and acetylcholine in modulating neuroimaging signals and neurovascular coupling
  • The neuronal and neurovascular effects of transcranial direct current stimulation
  • The impact of system inflammation on neurovascular coupling

Professor Paul Overton

  • Regulation of dopaminergic neurons by sensory afferents
  • Neuroadaptations which underlie the effects of drugs of abuse
  • Basal ganglia structure and function
  • Basal ganglia and emotional processing

Professor Peter Redgrave

  • Understanding normal brain function to better diagnose what goes wrong in complicated systems
  • The computational processes performed by the basal ganglia
  • How the superior colliculus interacts with the basal ganglia

Dr Robert Schmidt

  • Neural mechanisms underlying action control.
  • How different circuits in the basal ganglia contribute to the control of actions and how this can be modulated
  • Combining computational models with electrophysiological data